CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031971
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Conserved oligomeric Golgi complex subunit 2 
Protein Synonyms/Alias
 cDNA FLJ55945, highly similar to Conserved oligomeric Golgi complex component 2 
Gene Name
 COG2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60AVDERMSKQEDIRKKubiquitination[1]
86RSVEKIEKILNSQSSubiquitination[1]
94ILNSQSSKETSALEAubiquitination[1, 2, 3, 4]
129QFHAVQSKGMPLLDKubiquitination[1]
136KGMPLLDKVRPRIAGubiquitination[1]
180RTYATIDKTRDAEALubiquitination[1]
320AYHSFNKKWNLPVYFubiquitination[1]
417ESPKEIKKPLVTGSKubiquitination[3]
424KPLVTGSKEPSITQGubiquitination[3]
444GSGPSETKPVVSISRubiquitination[2, 3]
525DSCFGFLKSALEVPRubiquitination[1, 3]
539RLYRRTNKEVPTTASubiquitination[1]
568SGHKDKLKQAIIQQWubiquitination[1]
599SDVLNSVKKMEESLKubiquitination[1]
600DVLNSVKKMEESLKRubiquitination[1]
613KRLKQARKTTPANPVubiquitination[1]
631GGMSDDDKIRLQLALubiquitination[1]
658GLQASDIKSFSALAEubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 679 AA 
Protein Sequence
MVELINKDYA DFVNLSTNLV GMDKALNQLS VPLGQLREEV LSLRSSVSEG IRAVDERMSK 60
QEDIRKKKMC VLRLIQVIRS VEKIEKILNS QSSKETSALE ASSPLLTGQI LERIATEFNQ 120
LQFHAVQSKG MPLLDKVRPR IAGITAMLQQ SLEGLLLEGL QTSDVDIIRH CLRTYATIDK 180
TRDAEALVGQ VLVKPYIDEV IIEQFVESHP NGLQVMYNKL LEFVPHHCRL LREVTGGAIS 240
SEKGNTVPGY DFLVNSVWPQ IVQGLEEKLP SLFNPGNPDA FHEKYTISMD FVRRLERQCG 300
SQASVKRLRA HPAYHSFNKK WNLPVYFQIR FREIAGSLEA ALTDVLEDAP AESPYCLLAS 360
HRTWSSLRRC WSDEMFLPLL VHRLWRLTLQ ILARYSVFVN ELSLRPISNE SPKEIKKPLV 420
TGSKEPSITQ GNTEDQGSGP SETKPVVSIS RTQLVYVVAD LDKLQEQLPE LLEIIKPKLE 480
MIGFKNFSSI SAALEDSQSS FSACVPSLSS KIIQDLSDSC FGFLKSALEV PRLYRRTNKE 540
VPTTASSYVD SALKPLFQLQ SGHKDKLKQA IIQQWLEGTL SESTHKYYET VSDVLNSVKK 600
MEESLKRLKQ ARKTTPANPV GPSGGMSDDD KIRLQLALDV EYLGEQIQKL GLQASDIKSF 660
SALAELVAAA KDQATAEQP 679 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0007030; P:Golgi organization; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:InterPro. 
Interpro
 IPR009316; COG2.
 IPR024603; COG_complex_COG2_C.
 IPR024602; COG_su2_N. 
Pfam
 PF06148; COG2
 PF12022; DUF3510 
SMART
  
PROSITE
  
PRINTS