CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025859
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase isoform 1 variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
287NDLLLKIKDTVLQRTubiquitination[1]
321MLTKNGPKVLEFNCRubiquitination[1]
521DLKAAGFKDPLLASGubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1046 AA 
Protein Sequence
RRRGRRARRA TRCLTHGFQA LSGFIFLWNF CFTDRTMAAR VLIIGSGGRE HTLAWKLAQS 60
HHVKQVLVAP GNAGTACSEK ISNTAISISD HTALAQFCKE KKIEFVVVGP EAPLAAGIVG 120
NLRSAGVQCF GPTAEAAQLE SSKRFAKEFM DRHGIPTAQW KAFTKPEEAC SFILSADFPA 180
LVVKASGLAA GKGVIVAKSK EEACKAVQEI MQEKAFGAAG ETIVIEELLD GEEVSCLCFT 240
DGKTVAPMPP AQDHKRLLEG DGGPNTGGMG AYCPAPQVSN DLLLKIKDTV LQRTVDGMQQ 300
EGTPYTGILY AGIMLTKNGP KVLEFNCRFG DPECQVILPL LKSDLYEVIQ STLDGLLCTS 360
LPVWLENHTA LTVVMASKGY PGDYTKGVEI TGFPEAQALG LEVFHAGTAL KNGKVVTHGG 420
RVLAVTAIRE NLISALEEAK KGLAAIKFEG AIYRKDIGFR AIAFLQQPRS LTYKESGVDI 480
AAGNMLVKKI QPLAKATSRS GCKVDLGGFA GLFDLKAAGF KDPLLASGTD GVGTKLKIAQ 540
LCNKHDTIGQ DLVAMCVNDI LAQGAEPLFF LDYFSCGKLD LSVTEAVVAG IAKACGKAGC 600
ALLGGETAEM PDMYPPGEYD LAGFAVGAME RDQKLPHLER ITEGDVVVGI ASSGLHSNGF 660
SLVRKIVAKS SLQYSSPAPD GCGDQTLGDL LLTPTRIYSH SLLPVLRSGH VKAFAHITGG 720
GLLENIPRVL PEKLGVDLDA QTWRIPRVFS WLQQEGHLSE EEMARTFNCG VGAVLVVSKE 780
QTEQILRDIQ QHKEEAWVIG SVVARAEGSP RVKVKNLIES MQINGSVLKN GSLTNHFSFE 840
KKKARVAVLI SGTGSNLQAL IDSTREPNSS AQIDIVISNK AAVAGLDKAE RAGIPTRVIN 900
HKLYKNRVEF DSAIDLVLEE FSIDIVCLAG FMRILSGPFV QKWNGKMLNI HPSLLPSFKG 960
SNAHEQALET GVTVTGCTVH FVAEDVDAGQ IILQEAVPVK RGDTVATLSE RVKLAEHKIF 1020
PAALQLVASG TVQLGENGKI CWVKEE 1046 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:InterPro.
 GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:InterPro.
 GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:InterPro.
 GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
 GO:0032259; P:methylation; IEA:GOC.
 GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro. 
Interpro
 IPR010918; AIR_synth_C_dom.
 IPR000728; AIR_synth_N_dom.
 IPR011761; ATP-grasp.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR002376; Formyl_transf_N.
 IPR001555; GART_AS.
 IPR016185; PreATP-grasp_dom.
 IPR020561; PRibGlycinamid_synth_ATP-grasp.
 IPR000115; PRibGlycinamide_synth.
 IPR020560; PRibGlycinamide_synth_C-dom.
 IPR020559; PRibGlycinamide_synth_CS.
 IPR020562; PRibGlycinamide_synth_N.
 IPR004733; PurM_cligase.
 IPR016188; PurM_N-like.
 IPR004607; PurN_trans.
 IPR011054; Rudment_hybrid_motif. 
Pfam
 PF00586; AIRS
 PF02769; AIRS_C
 PF00551; Formyl_trans_N
 PF01071; GARS_A
 PF02843; GARS_C
 PF02844; GARS_N 
SMART
  
PROSITE
 PS50975; ATP_GRASP
 PS00184; GARS
 PS00373; GART 
PRINTS