| Tag | Content |
|---|
| CPLM ID | CPLM-012666 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cyclic nucleotide-gated cation channel alpha-3 |
Protein Synonyms/Alias | Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3 |
Gene Name | CNGA3 |
Gene Synonyms/Alias | CNCG3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 138 | RSAWPLAKCNTNTSN | acetylation | [1] | | 154 | TEEEKKTKKKDAIVV | acetylation | [1] | | 155 | EEEKKTKKKDAIVVD | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. |
Sequence Annotation | NP_BIND 482 605 cGMP.
BINDING 549 549 cGMP (Potential).
BINDING 564 564 cGMP (Potential). |
Keyword | 3D-structure; Alternative splicing; cGMP; cGMP-binding; Coiled coil; Complete proteome; Disease mutation; Ion channel; Ion transport; Leber congenital amaurosis; Ligand-gated ion channel; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Sensory transduction; Transmembrane; Transmembrane helix; Transport; Vision. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 694 AA |
Protein Sequence | MAKINTQYSH PSRTHLKVKT SDRDLNRAEN GLSRAHSSSE ETSSVLQPGI AMETRGLADS 60
GQGSFTGQGI ARLSRLIFLL RRWAARHVHH QDQGPDSFPD RFRGAELKEV SSQESNAQAN 120
VGSQEPADRG RSAWPLAKCN TNTSNNTEEE KKTKKKDAIV VDPSSNLYYR WLTAIALPVF 180
YNWYLLICRA CFDELQSEYL MLWLVLDYSA DVLYVLDVLV RARTGFLEQG LMVSDTNRLW 240
QHYKTTTQFK LDVLSLVPTD LAYLKVGTNY PEVRFNRLLK FSRLFEFFDR TETRTNYPNM 300
FRIGNLVLYI LIIIHWNACI YFAISKFIGF GTDSWVYPNI SIPEHGRLSR KYIYSLYWST 360
LTLTTIGETP PPVKDEEYLF VVVDFLVGVL IFATIVGNVG SMISNMNASR AEFQAKIDSI 420
KQYMQFRKVT KDLETRVIRW FDYLWANKKT VDEKEVLKSL PDKLKAEIAI NVHLDTLKKV 480
RIFQDCEAGL LVELVLKLRP TVFSPGDYIC KKGDIGKEMY IINEGKLAVV ADDGVTQFVV 540
LSDGSYFGEI SILNIKGSKS GNRRTANIRS IGYSDLFCLS KDDLMEALTE YPEAKKALEE 600
KGRQILMKDN LIDEELARAG ADPKDLEEKV EQLGSSLDTL QTRFARLLAE YNATQMKMKQ 660
RLSQLESQVK GGGDKPLADG EVPGDATKTE DKQQ 694 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0001750; C:photoreceptor outer segment; IEA:Compara. GO:0005886; C:plasma membrane; IEA:Compara. GO:0030553; F:cGMP binding; IEA:UniProtKB-KW. GO:0005221; F:intracellular cyclic nucleotide activated cation channel activity; IEA:Compara. GO:0015276; F:ligand-gated ion channel activity; TAS:ProtInc. GO:0046549; P:retinal cone cell development; IEA:Compara. GO:0007165; P:signal transduction; TAS:ProtInc. GO:0007601; P:visual perception; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |