CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045623
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kynurenine formamidase 
Protein Synonyms/Alias
 KFA; KFase; Arylformamidase; N-formylkynurenine formamidase 
Gene Name
 Afmid 
Gene Synonyms/Alias
 rCG_34031 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
24LSSEELEKQYSPRRWacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (By similarity). 
Sequence Annotation
 ACT_SITE 163 163 Nucleophile (By similarity).
 ACT_SITE 248 248 By similarity.
 ACT_SITE 280 280 By similarity.  
Keyword
 Complete proteome; Cytoplasm; Hydrolase; Nucleus; Reference proteome; Tryptophan catabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
MALPSSPSPG QAPWRTLSSE ELEKQYSPRR WVIRMKTEEV VGNFMQIGSQ ATQKARATRR 60
NQLDVSYGDG VGEKMDIYFP DEDSKAFPLF MFLHGGYWQS GSKDDSAFMV NPLTAQGIVV 120
AVVAYDIAPK GTLDQMVDQV SRSVVFLQRR YPSNEGIYLC GHSAGAHLAA MMLLASWTKH 180
GVTPNIQGLL LVSGIYDLEP LVFTSQNDLL HMTLEDAERN SPQRLLEVAP ARPVVPAYPV 240
LVFVAQHDSP EFHRQSKEFC ETLRLAGWKA SFQELCGVDH FDIIENLTRE DYALTQIILK 300
MIFQKL 306 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004061; F:arylformamidase activity; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP.
 GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:InterPro. 
Interpro
 IPR013094; AB_hydrolase_3.
 IPR027519; KFase. 
Pfam
 PF07859; Abhydrolase_3 
SMART
  
PROSITE
  
PRINTS