UniProt Accession

 FHL1_MOUSE; P97447; O55181; Q8K318 

Genbank Protein ID

 U77039; U41739; AF114380; BC031120; BC029024 

Genbank Nucleotide ID

 AAC02727.1; AAC02805.1; AAD53229.1; AAH31120.1; AAH29024.1 

Protein Name

 Four and a half LIM domains protein 1 

Protein Synonyms/Alias

 FHL-1; KyoT; RBP-associated molecule 14-1; RAM14-1; Skeletal muscle LIM-protein 1; SLIM; SLIM-1 

Gene Name

 Fhl1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
144	GTGSFFPKGEDFYCV	sumoylation	[1]
171	KCNKGLVKAPVWWPM	sumoylation	[1]

Reference

 [1] The transcriptional repression activity of KyoT2 on the Notch/RBP-J pathway is regulated by PIAS1-catalyzed SUMOylation.
 Wang J, Qin H, Liang J, Zhu Y, Liang L, Zheng M, Han H.
 J Mol Biol. 2007 Jun 29;370(1):27-38. [PMID: 17509614] 

Functional Description

 May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems. 

Sequence Annotation

 DOMAIN 40 92 LIM zinc-binding 1.
 DOMAIN 101 153 LIM zinc-binding 2.
 DOMAIN 162 212 LIM zinc-binding 3.
 DOMAIN 221 276 LIM zinc-binding 4.
 ZN_FING 7 31 C4-type (Potential).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 280 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS