CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023473
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centromere/kinetochore protein zw10 
Protein Synonyms/Alias
 Mitotic 15 protein 
Gene Name
 mit(1)15 
Gene Synonyms/Alias
 zw10; CG9900 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
99ALDEANVKMAGNGRQacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. 
Sequence Annotation
  
Keyword
 Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 721 AA 
Protein Sequence
MEEEAPRFNV LEEAFNGNGN GCANVEATQS AILKVLTRVN RFQMRVRKHI EDNYTEFLPN 60
NTSPDIFLEE SGSLNREIHD MLENLGSEGL DALDEANVKM AGNGRQLREI LLGLGVSEHV 120
LRIDELFQCV EEAKATKDYL VLLDLVGRLR AFIYGDDSVD GDAQVATPEV RRIFKALECY 180
ETIKVKYHVQ AYMLQQSLQE RFDRLVQLQC KSFPTSRCVT LQVSRDQTQL QDIVQALFQE 240
PYNPARLCEF LLDNCIEPVI MRPVMADYSE EADGGTYVRL SLSYATKEPS SAHVRPNYKQ 300
VLENLRLLLH TLAGINCSVS RDQHVFGIIG DHVKDKMLKL LVDECLIPAV PESTEEYQTS 360
TLCEDVAQLE QLLVDSFIIN PEQDRALGQF VEKYETYYRN RMYRRVLETA REIIQRDLQD 420
MVLVAPNNHS AEVANDPFLF PRCMISKSAQ DFVKLMDRIL RQPTDKLGDQ EADPIAGVIS 480
IMLHTYINEV PKVHRKLLES IPQQAVLFHN NCMFFTHWVA QHANKGIESL AALAKTLQAT 540
GQQHFRVQVD YQSSILMGIM QEFEFESTHT LGSGPLKLVR QCLRQLELLK NVWANVLPET 600
VYNATFCELI NTFVAELIRR VFTLRDISAQ MACELSDLID VVLQRAPTLF REPNEVVQVL 660
SWLKLQQLKA MLNASLMEIT ELWGDGVGPL TASYKSDEIK HLIRALFQDT DWRAKAITQI 720
V 721 
Gene Ontology
 GO:0000940; C:condensed chromosome outer kinetochore; NAS:FlyBase.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005828; C:kinetochore microtubule; IDA:FlyBase.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007126; P:meiosis; IEA:UniProtKB-KW.
 GO:0000070; P:mitotic sister chromatid segregation; IMP:FlyBase.
 GO:0007094; P:mitotic spindle assembly checkpoint; NAS:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0040020; P:regulation of meiosis; NAS:FlyBase. 
Interpro
 IPR009361; RZZ-complex_Zw10. 
Pfam
 PF06248; Zw10 
SMART
  
PROSITE
  
PRINTS