UniProt Accession

 URM1_MOUSE; Q9D2P4; A3KGW2; Q8BHY9 

Genbank Protein ID

 AK019352; AK049227; AK049849; AL928926; CH466542; BC026994 

Genbank Nucleotide ID

 BAB31673.1; BAC33621.1; BAC33956.1; CAM46216.1; EDL08423.1; AAH26994.1 

Protein Name

 Ubiquitin-related modifier 1 homolog 

Protein Synonyms/Alias

  

Gene Name

 Urm1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	LLFDGVKKHQVALPG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo (By similarity). 

Sequence Annotation

 MOD_RES 101 101 1-thioglycine (By similarity).
 CROSSLNK 101 101 Glycyl lysine isopeptide (Gly-Lys)  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Isopeptide bond; Reference proteome; tRNA processing; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 101 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016783; F:sulfurtransferase activity; IEA:Compara.
 GO:0034227; P:tRNA thio-modification; ISS:UniProtKB.
 GO:0002098; P:tRNA wobble uridine modification; ISS:UniProtKB. 

Interpro

 IPR012675; Beta-grasp_dom.
 IPR016155; Mopterin_synth/thiamin_S_b.
 IPR015221; Urm1. 

Pfam

 PF09138; Urm1 

SMART

  

PROSITE

  

PRINTS