CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026888
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LRRGT00050 
Protein Synonyms/Alias
 Protein Eprs 
Gene Name
 Eprs 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
261FDDTNPEKEKEDFEKacetylation[1]
263DTNPEKEKEDFEKVIacetylation[1]
300TIMKYAEKLIEEGKAacetylation[1]
423IEALGIRKPYIWEYSacetylation[1]
471DKIWAFNKKVIDPVAacetylation[1]
472KIWAFNKKVIDPVAPacetylation[1]
502LDAQEEMKEVARHPKacetylation[1]
509KEVARHPKNPDVGLKacetylation[1]
516KNPDVGLKPVWYSPKacetylation[1]
573AKLNLENKDYKKTTKacetylation[1]
762VKQLLTLKAEYKEKTacetylation[1]
835VECLLSLKAEYKEKTacetylation[1]
913VQELLQLKAQYKSLTacetylation[1]
925SLTGIEYKPVSATGAacetylation[1]
983AGEGQGPKKQTRLGLubiquitination[2]
1130NVVRWEFKHPQPFLRacetylation[1]
1363VRRDTGEKLTIAEKEacetylation[1]
1369EKLTIAEKEAESKLKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1486 AA 
Protein Sequence
MAALCLTVNA GNPPLGCRVK VNKRNKSFML SFLEALLAVE HVKGDVSISV EEGKENLLRV 60
SESVVFTDTN SILRYLARVA ATSGLYGSNL MEHTEIDHWL EFSATKLSSC DVLTSAIKEL 120
NHCLSLRTYL VGNSLTLADL CVWATLKGNA ACQEHLRQSK TLVHVNRWYG FLEAQQAFRS 180
VGTKWDASAN KATGAPDRKQ DIGKFVELPG AEMGKVTVRF PPEASGYLHI GHAKAALLNQ 240
HYQVNFKGKL IMRFDDTNPE KEKEDFEKVI LEDVAMLHIK PDQFTYTSDH FETIMKYAEK 300
LIEEGKAYVD DTPADEMKAE PVEKNLQMWE EMKRGSQFGQ SCCLRAKIDM SSNNGCMRDP 360
TLYRCKIQPH PRTGNKYNVY PTYDFACPIV DSIEGVTHAL RTTEYHDRDE QFYWIIEALG 420
IRKPYIWEYS RLNLNNTVLS KRKLTWFVNE GLGSSRSVVN MEWDKIWAFN KKVIDPVAPR 480
YVALLKKEVI PVNILDAQEE MKEVARHPKN PDVGLKPVWY SPKVFIEGAD AETFSEGEMV 540
TFINWGNINI TKIHKNPDGK ITSLDAKLNL ENKDYKKTTK ITWLAETTQA LPVPAVCVTY 600
EHLITKPVLG KDEDFKQYVN KDSKHEELML GDPCLKDLKK GDIIQLQRRG FFICDQPYEP 660
VSPYSCKEAP CILIYIPDGH TKEMPTSGSK EKTKVEISKK ETGSAPKERP AAAVSAPCAA 720
AEDAAILYSR VAVQGDAVRD LKAKKAPKED IDAAVKQLLT LKAEYKEKTG QEYRPGNPPT 780
AAVQTVSTKS PSNTGEYTSL YNKVAAQGEL VRKLKAEKAP KAKINDAVEC LLSLKAEYKE 840
KTGKEYVPGQ LPASQNSHSS PVSNAKPVGS ETPEAKLLFD RVACQGEVVR KLKAEKASKD 900
QVDSAVQELL QLKAQYKSLT GIEYKPVSAT GAEDKDKKKK EKENKSEKQN KPQKQNDGQG 960
KDSSKSQGSG LSSGGAGEGQ GPKKQTRLGL EAKKEENLAE WYSQVITKSE MIEYYDVSGC 1020
YILRPWSYSI WESIKDFFDA EIKKLGVENC YFPIFVSQGA LEKEKNHIAD FAPEVAWVTR 1080
SGKTELAEPI AIRPTSETVM YPAYAKWVQS HRDLPIRLNQ WCNVVRWEFK HPQPFLRTRE 1140
FLWQEGHSAF ATFEEAADEV LQILELYARV YEELLAIPVV RGRKTEKEKF AGGDYTTTLE 1200
AFISASGRAI QGATSHHLGQ NFSKMCEIVF EDPKTPGEKQ FAYQCSWGLT TRTIGVMIMV 1260
HGDNMGLVLP PRVASVQVVV IPCGITNTLS EEDREALMAK CNEYRRRLLG ADIRARVDLR 1320
DNYSPGWKFN HWELKGVPVR LEVGPRDMKS CQFVAVRRDT GEKLTIAEKE AESKLKGVLE 1380
DIQLNLFTRA SEDLKSHMVV SDTLEDFQKV LDSGKVAQIP FCGEIDCEDW IKKTTARDQD 1440
VEPGAPSMGA KSLCIPFNPL CELQPGAMCV CGKNPAKFYT LFGRSY 1486 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0030529; C:ribonucleoprotein complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004827; F:proline-tRNA ligase activity; IEA:InterPro.
 GO:0035613; F:RNA stem-loop binding; IEA:Compara.
 GO:0071346; P:cellular response to interferon-gamma; IEA:Compara.
 GO:0017148; P:negative regulation of translation; IEA:Compara.
 GO:0006433; P:prolyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR001412; aa-tRNA-synth_I_CS.
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR000924; Glu/Gln-tRNA-synth_Ib.
 IPR020058; Glu/Gln-tRNA-synth_Ib_cat-dom.
 IPR020059; Glu/Gln-tRNA-synth_Ib_codon-bd.
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004499; Pro-tRNA-ligase_IIa_arc-type.
 IPR016061; Pro-tRNA_ligase_II_C.
 IPR017449; Pro-tRNA_synth_II.
 IPR020056; Rbsml_L25/Gln-tRNA_synth_b-brl.
 IPR011035; Ribosomal_L25/Gln-tRNA_synth.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009068; S15_NS1_RNA-bd.
 IPR000738; WHEP-TRS. 
Pfam
 PF03129; HGTP_anticodon
 PF09180; ProRS-C_1
 PF00749; tRNA-synt_1c
 PF03950; tRNA-synt_1c_C
 PF00587; tRNA-synt_2b
 PF00458; WHEP-TRS 
SMART
 SM00946; ProRS-C_1
 SM00991; WHEP-TRS 
PROSITE
 PS00178; AA_TRNA_LIGASE_I
 PS50862; AA_TRNA_LIGASE_II
 PS00762; WHEP_TRS_1
 PS51185; WHEP_TRS_2 
PRINTS
 PR00987; TRNASYNTHGLU.