CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042502
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA mismatch repair protein Mlh1 
Protein Synonyms/Alias
  
Gene Name
 MLH1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25QRPANAIKEMIENCLubiquitination[1]
49IVKEGGLKLIQIQDNubiquitination[1]
62DNGTGIRKEDLDIVCubiquitination[1]
76CERFTTSKLQSFEDLubiquitination[1, 2]
167NPSEEYGKILEVVGRubiquitination[1]
188GISFSVKKQGETVADubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 679 AA 
Protein Sequence
XRLDETVVNR IAAGEVIQRP ANAIKEMIEN CLDAKSTSIQ VIVKEGGLKL IQIQDNGTGI 60
RKEDLDIVCE RFTTSKLQSF EDLASISTYG FRGEALASIS HVAHVTITTK TADGKCAYRA 120
SYSDGKLKAP PKPCAGNQGT QITVEDLFYN IATRRKALKN PSEEYGKILE VVGRYSVHNA 180
GISFSVKKQG ETVADVRTLP NASTVDNIRS IFGNAVSREL IEIGCEDKTL AFKMNGYISN 240
ANYSVKKCIF LLFINHRLVE STSLRKAIET VYAAYLPKNT HPFLYLSLEI SPQNVDVNVH 300
PTKHEVHFLH EESILERVQQ HIESKLLGSN SSRMYFTQTL LPGLAGPSGE MVKSTTSLTS 360
SSTSGSSDKV YAHQMVRTDS REQKLDAFLQ PLSKPLSSQP QAIVTEDKTD ISSGRARQQD 420
EEMLELPAPA EVAAKNQSLE GDTTKGTSEM SEKRGPTSSN PRKRHREDSD VEMVEDDSRK 480
EMTAACTPRR RIINLTSVLS LQEEINEQGH EVLREMLHNH SFVGCVNPQW ALAQHQTKLY 540
LLNTTKLSEE LFYQILIYDF ANFGVLRLSE PAPLFDLAML ALDSPESGWT EEDGPKEGLA 600
EYIVEFLKKK AEMLADYFSL EIDESEVPGS IPNSWKWTVE HIVYKALRSH ILPPKHFTED 660
GNILQLANLP DLYKVFERC 679 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0030983; F:mismatched DNA binding; IEA:InterPro.
 GO:0006298; P:mismatch repair; IEA:InterPro. 
Interpro
 IPR002099; DNA_mismatch_repair.
 IPR013507; DNA_mismatch_repair_C.
 IPR014762; DNA_mismatch_repair_CS.
 IPR011186; DNA_mismatch_repair_MLH1.
 IPR014763; DNA_mismatch_repair_N.
 IPR003594; HATPase_ATP-bd.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF01119; DNA_mis_repair 
SMART
 SM00387; HATPase_c 
PROSITE
 PS00058; DNA_MISMATCH_REPAIR_1 
PRINTS