CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031447
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein transport protein Sec24C 
Protein Synonyms/Alias
 cDNA FLJ60379, highly similar to Protein transport protein Sec24C 
Gene Name
 SEC24C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
101TLINYMAKFAYRGVLubiquitination[1, 2, 3]
113GVLNSPVKAVRDTLIubiquitination[2, 3]
132QILACYRKNCASPSSubiquitination[2]
161VYLNCVLKSDVLQPGubiquitination[1, 2]
204PRLLPLTKSPVESTTubiquitination[1, 2, 3, 4]
296AQRSRYMKLTVVKQEubiquitination[2, 5]
305TVVKQEDKMEMLFKHubiquitination[2, 3]
335DFLCHMHKEIRQLLSacetylation[3]
335DFLCHMHKEIRQLLSubiquitination[2, 3]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 342 AA 
Protein Sequence
MRVRTSTGIR AVDFFGAFYM SNTTDVELAG LDGDKTVTVE FKHDDRLNEE SGALLQCALL 60
YTSCAGQRRL RIHNLALNCC TQLADLYRNC ETDTLINYMA KFAYRGVLNS PVKAVRDTLI 120
TQCAQILACY RKNCASPSSA GQLILPECMK LLPVYLNCVL KSDVLQPGAE VTTDDRAYVR 180
QLVTSMDVTE TNVFFYPRLL PLTKSPVEST TEPPAVRASE ERLSNGDIYL LENGLNLFLW 240
VGASVQQGVV QSLFSVSSFS QITSGLSVLP VLDNPLSKKV RGLIDSLRAQ RSRYMKLTVV 300
KQEDKMEMLF KHFLVEDKSL SGGASYVDFL CHMHKEIRQL LS 342 
Gene Ontology
 GO:0030127; C:COPII vesicle coat; IEA:InterPro.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR007123; Gelsolin_dom.
 IPR006900; Sec23/24_helical_dom.
 IPR012990; Sec23_24_beta_S. 
Pfam
 PF00626; Gelsolin
 PF08033; Sec23_BS
 PF04815; Sec23_helical 
SMART
  
PROSITE
  
PRINTS