CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012681
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 
Protein Synonyms/Alias
 PP2A B subunit isoform B'-epsilon; PP2A B subunit isoform B56-epsilon; PP2A B subunit isoform PR61-epsilon; PP2A B subunit isoform R5-epsilon 
Gene Name
 PPP2R5E 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41SQFRSQGKPIELTPLubiquitination[1]
173EFQPSIAKKYIDQKFubiquitination[1, 2]
174FQPSIAKKYIDQKFVubiquitination[1]
200PRERDYLKTVLHRIYubiquitination[2]
209VLHRIYGKFLGLRAFubiquitination[1]
308PVIRGLMKFWPKTCSubiquitination[1]
346KIQEPLFKQIAKCVSubiquitination[1]
449EREELWKKLEDLELKubiquitination[1]
456KLEDLELKRGLRRDGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. 
Sequence Annotation
 MOD_RES 30 30 Phosphoserine.
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 34 34 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 467 AA 
Protein Sequence
MSSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL LKDVPSSEQP 60
ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI TISRGCLTEQ TYPEVVRMVS 120
CNIFRTLPPS DSNEFDPEED EPTLEASWPH LQLVYEFFIR FLESQEFQPS IAKKYIDQKF 180
VLQLLELFDS EDPRERDYLK TVLHRIYGKF LGLRAFIRKQ INNIFLRFVY ETEHFNGVAE 240
LLEILGSIIN GFALPLKAEH KQFLVKVLIP LHTVRSLSLF HAQLAYCIVQ FLEKDPSLTE 300
PVIRGLMKFW PKTCSQKEVM FLGELEEILD VIEPSQFVKI QEPLFKQIAK CVSSPHFQVA 360
ERALYYWNNE YIMSLIEENS NVILPIMFSS LYRISKEHWN PAIVALVYNV LKAFMEMNST 420
MFDELTATYK SDRQREKKKE KEREELWKKL EDLELKRGLR RDGIIPT 467 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
 GO:0008601; F:protein phosphatase type 2A regulator activity; TAS:ProtInc.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR002554; PP2A_B56. 
Pfam
 PF01603; B56 
SMART
  
PROSITE
  
PRINTS