CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014546
UniProt Accession
Genbank Protein ID
 D45249 
Genbank Nucleotide ID
Protein Name
 Proteasome activator complex subunit 1 
Protein Synonyms/Alias
 11S regulator complex subunit alpha; REG-alpha; Activator of multicatalytic protease subunit 1; Proteasome activator 28 subunit alpha; PA28a; PA28alpha 
Gene Name
 Psme1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
35LLGSYFPKKISELDAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. 
Sequence Annotation
  
Keyword
 Complete proteome; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 249 AA 
Protein Sequence
MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP 60
LDIPVPDPVK EKEKEERKKQ QEKEEKDEKK KGDEDDKGPP CGPVNCNEKI VVLLQRLKPE 120
IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQAKVFELM TSLHTKLEGF QTQISKYFSE 180
RGDAVAKAAK QPHVGDYRQL VHELDEAEYQ EIRLMVMEIR NAYAVLYDII LKNFEKLKKP 240
RGETKGMIY 249 
Gene Ontology
 GO:0008537; C:proteasome activator complex; IEA:InterPro. 
Interpro
 IPR003185; Proteasome_activ_REG_asu.
 IPR009077; Proteasome_activ_REG_asu/bsu.
 IPR003186; Proteasome_activ_REG_bsu. 
Pfam
 PF02251; PA28_alpha
 PF02252; PA28_beta 
SMART
  
PROSITE
  
PRINTS