CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037250
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DENN domain-containing protein 4B 
Protein Synonyms/Alias
  
Gene Name
 DENND4B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
110CYRRGRDKPPLVELGubiquitination[1]
182LCLVLPSKGEGTPHTubiquitination[1]
621FFLQGFLKSRERSSHubiquitination[1]
766VAQRMAQKSAAVPELubiquitination[1]
873NKAVLESKWPSGTPGubiquitination[1]
971SPPGRLVKSGSLGSAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1218 AA 
Protein Sequence
MEADAVSEGG AMAEERPPRL VDYFVVAGLA GNGAPIPEET WVPEPSGPLR PPRPAEPITD 60
VAVIARALGE EVPQGYTCIQ ASAGGHPLEL SAGLLGGTQP VICYRRGRDK PPLVELGVLY 120
EGKERPKPGF QVLDTTPYSH SANLAPPGPG HPRTYLTYRR AAEGAGLHAL GITDLCLVLP 180
SKGEGTPHTY CRLPRNLNPG MWGPAVYLCY KVGLAKANTL VYEAELLGRY PEEDNEAFPL 240
PESVPVFCLP MGATIECWPA QTKYPVPVFS TFVLTGAAGD KVYGAALQFY EAFPRARLSE 300
RQARALGLLS AVERGRALGG RAVRSRRAIA VLSRWPAFPA FRAFLTFLYR YSVSGPHRLP 360
LEAHISHFIH NVPFPSPQRP RILVQMSPYD NLLLCQPVSS PLPLSGASFL QLLQSLGPEL 420
AITLLLAVLT EHKLLVHSLR PDLLTSVCEA LVSMIFPLHW QCPYIPLCPL VLADVLSAPV 480
PFIVGIHSSY FDLHDPPADV ICVDLDTNTL FQTEEKKLLS PRTLPRRPYK VLLATLTNLY 540
QQLDQTYTGP EEEASLEFLL TDYEAVCGRR ARLEREVQGA FLRFMACLLK GYRVFLRPLT 600
QAPSEGARDV DNLFFLQGFL KSRERSSHKL YSQLLHTQMF SQFIEECSFG SARHAALEFF 660
DSCVEKVHPE QEKPEPTPLV ELEELSGSEL TVFITPPEEP ALPEGSESTP QYCYDGFPEL 720
RAELFESLQE QPGALPVPGP SRSAPSSPAP RRTKQEMKVA QRMAQKSAAV PELWARCLLG 780
HCYGLWFLCL PAYVRSAPSR VQALHTAYHV LRQMESGKVV LPDEVCYRVL MQLCSHYGQP 840
VLSVRVMLEM RQAGIVPNTI TYGYYNKAVL ESKWPSGTPG GRLRWAKLRN VVLGAAQFRQ 900
PLRERQQQQQ QQQQQQQQQQ QEQVSAHQEA GSSQAEPYLE RPSPTRPLQR QTTWAGRSLR 960
DPASPPGRLV KSGSLGSARG AQPTVEAGVA HMIEALGVLE PRGSPVPWHD GSLSDLSLTG 1020
EEPLPGGSPG GSGSALSAQS TEALEGLSGR GPKAGGRQDE AGTPRRGLGA RLQQLLTPSR 1080
HSPASRIPPP ELPPDLPPPA RRSPMDSLLH PRERPGSTAS ESSASLGSEW DLSESSLSNL 1140
SLRRSSERLS DTPGSFQSPS LEILLSSCSL CRACDSLVYD EEIMAGWAPD DSNLNTTCPF 1200
CACPFVPLLS VQTLDSRP 1218 
Gene Ontology
  
Interpro
 IPR005112; dDENN_dom.
 IPR001194; DENN_dom.
 IPR023341; MABP.
 IPR002885; Pentatricopeptide_repeat.
 IPR005113; uDENN_dom. 
Pfam
 PF03455; dDENN
 PF02141; DENN
 PF03456; uDENN 
SMART
 SM00801; dDENN
 SM00799; DENN
 SM00800; uDENN 
PROSITE
 PS50947; DDENN
 PS50211; DENN
 PS51498; MABP
 PS51375; PPR
 PS50946; UDENN 
PRINTS