CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037896
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dipeptidyl peptidase 3 
Protein Synonyms/Alias
  
Gene Name
 DPP3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
100AYNTRLFKEVDGEGKubiquitination[1, 2, 3]
107KEVDGEGKPYYEVRLubiquitination[1, 2, 3]
131LDSEVTSKLKSYEFRubiquitination[1, 4, 5, 6]
133SEVTSKLKSYEFRGSubiquitination[1, 2, 3]
155DYAPILQKVVEQLEKubiquitination[1, 2, 3, 6]
162KVVEQLEKAKAYAANubiquitination[1, 2]
164VEQLEKAKAYAANSHubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 177 AA 
Protein Sequence
MGNYKSFGDT KFVPNLPKEK LERVILGSEA AQQHPEEVRG LWQTCGELMF SLEPRLRHLG 60
LGKEGITTYF SGNCTMEDAK LAQDFLDSQN LSAYNTRLFK EVDGEGKPYY EVRLASVLGS 120
EPSLDSEVTS KLKSYEFRGS PFQVTRGDYA PILQKVVEQL EKAKAYAANS HQGQMLA 177 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0008239; F:dipeptidyl-peptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:Compara. 
Interpro
 IPR005317; Dipeptidyl-peptase3. 
Pfam
  
SMART
  
PROSITE
  
PRINTS