UniProt Accession

 D6REF3_MOUSE; D6REF3 

Genbank Protein ID

 AL669897 

Genbank Nucleotide ID

  

Protein Name

 14-3-3 protein epsilon 

Protein Synonyms/Alias

  

Gene Name

 Ywhae 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
12	EDLVYQAKLAEQAER	acetylation	[1, 2]
12	EDLVYQAKLAEQAER	ubiquitination	[3]
29	EMVESMKKVAGMDVE	ubiquitination	[3]
50	NLLSVAYKNVIGARR	acetylation	[1, 2]
50	NLLSVAYKNVIGARR	ubiquitination	[3]
69	IISSIEQKEENKGGE	acetylation	[1, 4]
69	IISSIEQKEENKGGE	ubiquitination	[3]
73	IEQKEENKGGEDKLK	ubiquitination	[3]
78	ENKGGEDKLKMIREY	ubiquitination	[3]
106	DILDVLDKHLIPAAN	acetylation	[5]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 130 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0019904; F:protein domain specific binding; IDA:MGI.
 GO:0021987; P:cerebral cortex development; IMP:MGI.
 GO:0021766; P:hippocampus development; IMP:MGI.
 GO:0035308; P:negative regulation of protein dephosphorylation; IDA:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0006605; P:protein targeting; IDA:MGI. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1 

PRINTS

 PR00305; 1433ZETA.