CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037383
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dystonin 
Protein Synonyms/Alias
  
Gene Name
 DST 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50QKGRHPMKSVFSGRSubiquitination[1]
362TTCWRDGKLFNAIIHubiquitination[1]
3450EKRGITSKVLPLQLEubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Calcium; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 7750 AA 
Protein Sequence
MIAAAFLVLL RPYSIQCALF LLLLLLGTIA TIVFFCCWHR KLQKGRHPMK SVFSGRSRSR 60
DAVLRSHHFR SEGFRASPRH LRRRVAAAAA ARLEEVKPVV EVHHQSEQET SVRKRRIKKS 120
SRVQPEFYHS VQGASIRRPS SGNASYRCSM SSSADFSDED DFSQKSGSAS PAPGDTLPWN 180
LPKHERSKRK IQGGSVLDPA ERAVLRIADE RDKVQKKTFT KWINQHLMKV RKHVNDLYED 240
LRDGHNLISL LEVLSGDTLP REKGRMRFHR LQNVQIALDY LKRRQVKLVN IRNDDITDGN 300
PKLTLGLIWT IILHFQISDI HVTGESEDMS AKERLLLWTQ QATEGYAGIR CENFTTCWRD 360
GKLFNAIIHK YRPDLIDMNT VAVQSNLANL EHAFYVAEKI GVIRLLDPED VDVSSPDEKS 420
VITYVSSLYD AFPKVPEGGE GIGANDVEVK WIEYQNMVNY LIQWIRHHVT TMSERTFPNN 480
PVELKALYNQ YLQFKETEIP PKETEKSKIK RLYKLLEIWI EFGRIKLLQG YHPNDIEKEW 540
GKLIIAMLER EKALRPEVER LEMLQQIANR VQRDSVICED KLILAGNALQ SDSKRLESGV 600
QFQNEAEIAG YILECENLLR QHVIDVQILI DGKYYQADQL VQRVAKLRDE IMALRNECSS 660
VYSKGRILTT EQTKLMISGI TQSLNSGFAQ TLHPSLTSGL TQSLTPSLTS SSMTSGLSSG 720
MTSRLTPSVT PAYTPGFPSG LVPNFSSGVE PNSLQTLKLM QIRKPLLKSS LLDQNLTEEE 780
INMKFVQDLL NWVDEMQVQL DRTEWGSDLP SVESHLENHK NVHRAIEEFE SSLKEAKISE 840
IQMTAPLKLT YAEKLHRLES QYAKLLNTSR NQERHLDTLH NFVSRATNEL IWLNEKEEEE 900
VAYDWSERNT NIARKKDYHA ELMRELDQKE ENIKSVQEIA EQLLLENHPA RLTIEAYRAA 960
MQTQWSWILQ LCQCVEQHIK ENTAYFEFFN DAKEATDYLR NLKDAIQRKY SCDRSSSIHK 1020
LEDLVQESME EKEELLQYKS TIANLMGKAK TIIQLKPRNS DCPLKTSIPI KAICDYRQIE 1080
ITIYKDDECV LANNSHRAKW KVISPTGNEA MVPSVCFTVP PPNKEAVDLA NRIEQQYQNV 1140
LTLWHESHIN MKSVVSWHYL INEIDRIRAS NVASIKTMLP GEHQQVLSNL QSRFEDFLED 1200
SQESQVFSGS DITQLEKEVN VCKQYYQELL KSAEREEQEE SVYNLYISEV RNIRLRLENC 1260
EDRLIRQIRT PLERDDLHES VFRITEQEKL KKELERLKDD LGTITNKCEE FFSQAAASSS 1320
VPTLRSELNV VLQNMNQVYS MSSTYIDKLK TVNLVLKNTQ AAEALVKLYE TKLCEEEAVI 1380
ADKNNIENLI STLKQWRSEV DEKRQVFHAL EDELQKAKAI SDEMFKTYKE RDLDFDWHKE 1440
KADQLVERWQ NVHVQIDNRL RDLEGIGKSL KYYRDTYHPL DDWIQQVETT QRKIQENQPE 1500
NSKTLATQLN QQKMLVSEIE MKQSKMDECQ KYAEQYSATV KDYELQTMTY RAMVDSQQKS 1560
PVKRRRMQSS ADLIIQEFMD LRTRYTALVT LMTQYIKFAG DSLKRLEEEE KSLEEEKKEH 1620
VEKAKELQKW VSNISKTLKD AEKAGKPPFS KQKISSEEIS TKKEQLSEAL QTIQLFLAKH 1680
GDKMTDEERN ELEKQVKTLQ ESYNLLFSES LKQLQESQTS GDVKVEEKLD KVIAGTIDQT 1740
TGEVLSVFQA VLRGLIDYDT GIRLLETQLM ISGLISPELR KCFDLKDAKS HGLIDEQILC 1800
QLKELSKAKE IISAASPTTI PVLDALAQSM ITESMAIKVL EILLSTGSLV IPATGEQLTL 1860
QKAFQQNLVS SALFSKVLER QNMCKDLIDP CTSEKVSLID MVQRSTLQEN TGMWLLPVRP 1920
QEGGRITLKC GRNISILRAA HEGLIDRETM FRLLSAQLLS GGLINSNSGQ RMTVEEAVRE 1980
GVIDRDTASS ILTYQVQTGG IIQSNPAKRL TVDEAVQCDL ITSSSALLVL EAQRGYVGLI 2040
WPHSGEIFPT SSSLQQELIT NELAYKILNG RQKIAALYIP ESSQVIGLDA AKQLGIIDNN 2100
TASILKNITL PDKMPDLGDL EACKNARRWL SFCKFQPSTV HDYRQEEDVF DGEEPVTTQT 2160
SEETKKLFLS YLMINSYMDA NTGQRLLLYD GDLDEAVGML LEGCHAEFDG NTAIKECLDV 2220
LSSSGVFLNN ASGREKDECT ATPSSFNKCH CGEPEHEETP ENRKCAIDEE FNEMRNTVIN 2280
SEFSQSGKLA STISIDPKVN SSPSVCVPSL ISYLTQTELA DISMLRSDSE NILTNYENQS 2340
RVETNERANE CSHSKNIQNF PSDLIENPIM KSKMSKFCGV NETENEDNTN RDSPIFDYSP 2400
RLSALLSHDK LMHSQGSFND THTPESNGNK CEAPALSFSD KTMLSGQRIG EKFQDQFLGI 2460
AAINISLPGE QYGQKSLNMI SSNPQVQYHN DKYISNTSGE DEKTHPGFQQ MPEDKEDESE 2520
IEEYSCAVTP GGDTDNAIVS LTCATPLLDE TISASDYETS LLNDQQNNTG TDTDSDDDFY 2580
DTPLFEDDDH DSLLLDGDDR DCLHPEDYDT LQEENDETAS PADVFYDVSK ENENSMVPQG 2640
APVGSLSVKN KAHCLQDFLM DVEKDELDSG EKIHLNPVGS DKVNGQSLET GSERECTNIL 2700
EGDESDSLTD YDIVGGKESF TASLKFDDSG SWRGRKEEYV TGQEFHSDTD HLDSMQSEES 2760
YGDYIYDSND QDDDDDDGID EEGGGIRDEN GKPRCQNVAE DMDIQLCASI LNENSDENEN 2820
INTMILLDKM HSCSSLEKQQ RVNVVQLASP SENNLVTEKS NLPEYTTEIA GKSKENLLNH 2880
EMVLKDVLPP IIKDTESEKT FGPASISHDN NNISSTSELG TDLANTKVKL IQGSELPELT 2940
DSVKGKDEYF KNMTPKVDSS LDHIICTEPD LIGKPAEESH LSLIASVTDK DPQGNGSDLI 3000
KGRDGKSDIL IEDETSIQKM YLGEGEVLVE GLVEEENRHL KLLPGKNTRD SFKLINSQFP 3060
FPQITNNEEL NQKGSLKKAT VTLKDEPNNL QIIVSKSPVQ FENLEEIFDT SVSKEISDDI 3120
TSDITSWEGN THFEESFTDG PEKELDLFTY LKHCAKNIKA KDVAKPNEDV PSHVLITAPP 3180
MKEHLQLGVN NTKEKSTSTQ KDSPLNDMIQ SNDLCSKESI SGGGTEISQF TPESIEATLS 3240
ILSRKHVEDV GKNDFLQSER CANGLGNDNS SNTLNTDYSF LEINNKKERI EQQLPKEQAL 3300
SPRSQEKEVQ IPELSQVFVE DVKDILKSRL KEGHMNPQEV EEPSACADTK ILIQNLIKRI 3360
TTSQLVNEAS TVPSDSQMSD SSGVSPMTNS SELKPESRDD PFCIGNLKSE LLLNILKQDQ 3420
HSQKITGVFE LMRELTHMEY DLEKRGITSK VLPLQLENIF YKLLADGYSE KIEHVGDFNQ 3480
KACSTSEMME EKPHILGDIK SKEGNYYSPN LETVKEIGLE SSTVWASTLP RDEKLKDLCN 3540
DFPSHLECTS GSKEMASGDS STEQFSSELQ QCLQHTEKMH EYLTLLQDMK PPLDNQESLD 3600
NNLEALKNQL RQLETFELGL APIAVILRKD MKLAEEFLKS LPSDFPRGHV EELSISHQSL 3660
KTAFSSLSNV SSERTKQIML AIDSEMSKLA VSHEEFLHKL KSFSDWVSEK SKSVKDIEIV 3720
NVQDSEYVKK RLEFLKANNV LKDLGHTKMQ LETTAFDVQF FISEYAQDLS PNQSKQLLRL 3780
LNTTQKCFLD VQESVTTQVE RLETQLHLEQ DLDDQKIVAE RQQEYKEKLQ GICDLLTQTE 3840
NRLIGHQEAF MIGDGTVELK KYQSKQEELQ KDMQGSAQAL AEVVKNTENF LKENGEKLSQ 3900
EDKALIEQKL NEAKIKCEQL NLKAEQSKKE LDKVVTTAIK EETEKVAAVK QLEESKTKIE 3960
NLLDWLSNVD KDSERAGTKH KQVIEQNGTH FQEGDGKSAI GEEDEVNGNL LETDVDGQVG 4020
TTQENLNQQY QKVKAQHEKI ISQHQAVIIA TQSAQVLLEK QGQYLSPEEK EKLQKNMKEL 4080
KVHYETALAE SEKKMKLTHS LQEELEKFDA DYTEFEHWLQ QSEQELENLE AGADDINGLM 4140
TKLKRQKSFS EDVISHKGDL RYITISGNRV LEAAKSCSKR DGGKVDTSAT HREVQRKLDH 4200
ATDRFRSLYS KCNVLGNNLK DLVDKYQHYE DASCGLLAGL QACEATASKH LSEPIAVDPK 4260
NLQRQLEETK ALQGQISSQQ VAVEKLKKTA EVLLDARGSL LPAKNDIQKT LDDIVGRYED 4320
LSKSVNERNE KLQITLTRSL SVQDGLDEML DWMGNVESSL KEQGQVPLNS TALQDIISKN 4380
IMLEQDIAGR QSSINAMNEK VKKFMETTDP STASSLQAKM KDLSARFSEA SHKHKETLAK 4440
MEELKTKVEL FENLSEKLQT FLETKTQALT EVDVPGKDVT ELSQYMQEST SEFLEHKKHL 4500
EVLHSLLKEI SSHGLPSDKA LVLEKTNNLS KKFKEMEDTI KEKKEAVTSC QEQLDAFQVL 4560
VKSLKSWIKE TTKKVPIVQP SFGAEDLGKS LEDTKKLQEK WSLKTPEIQK VNNSGISLCN 4620
LISAVTTPAK AIAAVKSGGA VLNGEGTATN TEEFWANKGL TSIKKDMTDI SHGYEDLGLL 4680
LKDKIAELNT KLSKLQKAQE ESSAMMQWLQ KMNKTATKWQ QTPAPTDTEA VKTQVEQNKS 4740
FEAELKQNVN KVQELKDKLT ELLEENPDTP EAPRWKQMLT EIDSKWQELN QLTIDRQQKL 4800
EESSNNLTQF QTVEAQLKQW LVEKELMVSV LGPLSIDPNM LNTQRQQVQI LLQEFATRKP 4860
QYEQLTAAGQ GILSRPGEDP SLRGIVKEQL AAVTQKWDSL TGQLSDRCDW IDQAIVKSTQ 4920
YQSLLRSLSD KLSDLDNKLS SSLAVSTHPD AMNQQLETAQ KMKQEIQQEK KQIKVAQALC 4980
EDLSALVKEE YLKAELSRQL EGILKSFKDV EQKAENHVQH LQSACASSHQ FQQMSRDFQA 5040
WLDTKKEEQN KSHPISAKLD VLESLIKDHK DFSKTLTAQS HMYEKTIAEG ENLLLKTQGS 5100
EKAALQLQLN TIKTNWDTFN KQVKERENKL KESLEKALKY KEQVETLWPW IDKCQNNLEE 5160
IKFCLDPAEG ENSIAKLKSL QKEMDQHFGM VELLNNTANS LLSVCEIDKE VVTDENKSLI 5220
QKVDMVTEQL HSKKFCLENM TQKFKEFQEV SKESKRQLQC AKEQLDIHDS LGSQAYSNKY 5280
LTMLQTQQKS LQALKHQVDL AKRLAQDLVV EASDSKGTSD VLLQVETIAQ EHSTLSQQVD 5340
EKCSFLETKL QGIGHFQNTI REMFSQFAEF DDELDSMAPV GRDAETLQKQ KETIKAFLKK 5400
LEALMASNDN ANKTCKMMLA TEETSPDLVG IKRDLEALSK QCNKLLDRAQ AREEQVEGTI 5460
KRLEEFYSKL KEFSILLQKA EEHEESQGPV GMETETINQQ LNMFKVFQKE EIEPLQGKQQ 5520
DVNWLGQGLI QSAAKSTSTQ GLEHDLDDVN ARWKTLNKKV AQRAAQLQEA LLHCGRFQDA 5580
LESLLSWMVD TEELVANQKP PSAEFKVVKA QIQEQKLLQR LLDDRKSTVE VIKREGEKIA 5640
TTAEPADKVK ILKQLSLLDS RWEALLNKAE TRNRQLEGIS VVAQQFHETL EPLNEWLTTI 5700
EKRLVNCEPI GTQASKLEEQ IAQHKALEDD IINHNKHLHQ AVSIGQSLKV LSSREDKDMV 5760
QSKLDFSQVW YIEIQEKSHS RSELLQQALC NAKIFGEDEV ELMNWLNEVH DKLSKLSVQD 5820
YSTEGLWKQQ SELRVLQEDI LLRKQNVDQA LLNGLELLKQ TTGDEVLIIQ DKLEAIKARY 5880
KDITKLSTDV AKTLEQALQL ARRLHSTHEE LCTWLDKVEV ELLSYETQVL KGEEASQAQM 5940
RPKELKKEAK NNKALLDSLN EVSSALLELV PWRAREGLEK MVAEDNERYR LVSDTITQKV 6000
EEIDAAILRS QQFDQAADAE LSWITETEKK LMSLGDIRLE QDQTSAQLQV QKTFTMEILR 6060
HKDIIDDLVK SGHKIMTACS EEEKQSMKKK LDKVLKNYDT ICQINSERYL QLERAQSLVN 6120
QFWETYEELW PWLTETQSII SQLPAPALEY ETLRQQQEEH RQLRELIAEH KPHIDKMNKT 6180
GPQLLELSPG EGFSIQEKYV AADTLYSQIK EDVKKRAVAL DEAISQSTQF HDKIDQILES 6240
LERIVERLRQ PPSISAEVEK IKEQISENKN VSVDMEKLQP LYETLKQRGE EMIARSGGTD 6300
KDISAKAVQD KLDQMVFIWE NIHTLVEERE AKLLDVMELA EKFWCDHMSL IVTIKDTQDF 6360
IRDLEDPGID PSVVKQQQEA AETIREEIDG LQEELDIVIN LGSELIAACG EPDKPIVKKS 6420
IDELNSAWDS LNKAWKDRID KLEEAMQAAV QYQDGLQAVF DWVDIAGGKL ASMSPIGTDL 6480
ETVKQQIEEL KQFKSEAYQQ QIEMERLNHQ AELLLKKVTE ESDKHTVQDP LMELKLIWDS 6540
LEERIINRQH KLEGALLALG QFQHALDELL AWLTHTEGLL SEQKPVGGDP KAIEIELAKH 6600
HVLQNDVLAH QSTVEAVNKA GNDLIESSAG EEASNLQNKL EVLNQRWQNV LEKTEQRKQQ 6660
LDGALRQAKG FHGEIEDLQQ WLTDTERHLL ASKPLGGLPE TAKEQLNVHM EVCAAFEAKE 6720
ETYKSLMQKG QQMLARCPKS AETNIDQDIN NLKEKWESVE TKLNERKTKL EEALNLAMEF 6780
HNSLQDFINW LTQAEQTLNV ASRPSLILDT VLFQIDEHKV FANEVNSHRE QIIELDKTGT 6840
HLKYFSQKQD VVLIKNLLIS VQSRWEKVVQ RLVERGRSLD DARKRAKQFH EAWSKLMEWL 6900
EESEKSLDSE LEIANDPDKI KTQLAQHKEF QKSLGAKHSV YDTTNRTGRS LKEKTSLADD 6960
NLKLDDMLSE LRDKWDTICG KSVERQNKLE EALLFSGQFT DALQALIDWL YRVEPQLAED 7020
QPVHGDIDLV MNLIDNHKAF QKELGKRTSS VQALKRSARE LIEGSRDDSS WVKVQMQELS 7080
TRWETVCALS ISKQTRLEAA LRQAEEFHSV VHALLEWLAE AEQTLRFHGV LPDDEDALRT 7140
LIDQHKEFMK KLEEKRAELN KATTMGDTVL AICHPDSITT IKHWITIIRA RFEEVLAWAK 7200
QHQQRLASAL AGLIAKQELL EALLAWLQWA ETTLTDKDKE VIPQEIEEVK ALIAEHQTFM 7260
EEMTRKQPDV DKVTKTYKRR AADPSSLQSH IPVLDKGRAG RKRFPASSLY PSGSQTQIET 7320
KNPRVNLLVS KWQQVWLLAL ERRRKLNDAL DRLEELREFA NFDFDIWRKK YMRWMNHKKS 7380
RVMDFFRRID KDQDGKITRQ EFIDGILSSK FPTSRLEMSA VADIFDRDGD GYIDYYEFVA 7440
ALHPNKDAYK PITDADKIED EVTRQVAKCK CAKRFQVEQI GDNKYRVSFQ SNFGDSQQLR 7500
LVRILRSTVM VRVGGGWMAL DEFLVKNDPC RVHHHGSKML RSESNSSITT TQPTIAKGRT 7560
NMELREKFIL ADGASQGMAA FRPRGRRSRP SSRGASPNRS TSVSSQAAQA ASPQVPATTT 7620
PKGTPIQGSK LRLPGYLSGK GFHSGEDSGL ITTAAARVRT QFADSKKTPS RPGSRAGSKA 7680
GSRASSRRGS DASDFDISEI QSVCSDVETV PQTHRPTPRA GSRPSTAKPS KIPTPQRKSP 7740
ASKLDKSSKR 7750 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; IEA:InterPro. 
Interpro
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR003108; GAS2_dom.
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF13499; EF_hand_5
 PF02187; GAS2
 PF00681; Plectin
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00054; EFh
 SM00243; GAS2
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51460; GAR 
PRINTS