CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026093
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cyclin-dependent kinase 11A 
Protein Synonyms/Alias
  
Gene Name
 CDK11A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
644ELGTPSEKIWPGYSEubiquitination[1, 2]
656YSELPVVKKMTFSEHubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 779 AA 
Protein Sequence
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHCMEI 60
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR KDEKRKEKWK HARVKEREHE 120
RRKRHREEQD KARREWERQK RREMAREHSR RERGNDGVCL FRDRLEQLER KRERERKMRE 180
QQKEQREQKE RERRAEERRK EREARREVSA HHRTMREDYS DKVKASHWSR SPPRPPRERF 240
ELGDGRKPVK EEKMEERDLL SDLQDISDSE RKTSSAESSS AESGSGSEEE EEEEEEEEEE 300
GSTSEESEEE EEEEEEEEEE TGSNSEEASE QSAEEVSEEE MSEDEERENE NHLLVVPESR 360
FDRDSGESEE AEEEVGEGTP QSSALTEGDY VPDSPALLPI ELKQELPKYL PALQGCRSVE 420
EFQCLNRIEE GTYGVVYRAK DKKTDEIVAL KRLKMEKEKE GFPITSLREI NTILKAQHPN 480
IVTVREIVVG SNMDKIYIVM NYVEHDLKSL METMKQPFLP GEVKTLMIQL LRGVKHLHDN 540
WILHRDLKTS NLLLSHAGIL KVGDFGLARE YGSPLKAYTP VVVTQWYRAP ELLLGAKEYS 600
TAVDMWSVGC IFGELLTQKP LFPGNSEIDQ INKVFKELGT PSEKIWPGYS ELPVVKKMTF 660
SEHPYNNLRK RFGALLSDQG FDLMNKFLTY FPGRRISAED GLKHEYFRET PLPIDPSMFP 720
TWPAKSEQQR VKRGTSPRPP EGGLGYSQLG DDDLKETGFH LTTTNQGASA AGPGFSLKF 779 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS