UniProt Accession

 H2A_ONCMY; P02264; P83327 

Genbank Protein ID

 X01064 

Genbank Nucleotide ID

 CAA25528.1 

Protein Name

 Histone H2A 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 

NCBI Taxa ID

 8022 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKTGGKARA	acetylation	[1]

Reference

 [1] Acetylation of trout testis histones in vivo. Site of the modification in histone IIb 1 .
 Peter E, Candido M, Dixon GH.
 J Biol Chem. 1972 Jun 25;247(12):3868-73. [PMID: 5033394] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine (Probable).
 MOD_RES 6 6 N6-acetyllysine.
 CROSSLNK 14 14 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 16 16 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 120 120 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Antibiotic; Antimicrobial; Chromosome; Direct protein sequencing; DNA-binding; Fungicide; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
 GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
 GO:0031640; P:killing of cells of other organism; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.