CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040064
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Set1/Ash2 histone methyltransferase complex subunit ASH2 
Protein Synonyms/Alias
  
Gene Name
 ASH2L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106EHPDPGSKDPEEDYPacetylation[1]
199PLEHPFNKDGYRYILubiquitination[2, 3, 4]
254HDRAPQLKISDDRLTubiquitination[3, 4]
266RLTVVGEKGYSMVRAubiquitination[3]
368KSLPDTYKDKALIKFubiquitination[3]
370LPDTYKDKALIKFKSubiquitination[3]
392DFVDKAEKSLKQTPHubiquitination[3, 4]
395DKAEKSLKQTPHSEIubiquitination[3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 489 AA 
Protein Sequence
MTNYSFHCNV CHHSGNTYFL RKQANLKEMC LSALANLTWQ SRTQDEHPKT MFSKDKDIIP 60
FIDKYWECMT TRQRPGKMTW PNNIVKTMSK ERDVFLVKEH PDPGSKDPEE DYPKFGLLDQ 120
DLSNIGPAYD NQKQSSAVST SGNLNGGIAA GSSGKGRGAK RKQQDGGTTG TTKKARSDPL 180
FSAQRLPPHG YPLEHPFNKD GYRYILAEPD PHAPDPEKLE LDCWAGKPIP GDLYRACLYE 240
RVLLALHDRA PQLKISDDRL TVVGEKGYSM VRASHGVRKG AWYFEITVDE MPPDTAARLG 300
WSQPLGNLQA PLGYDKFSYS WRSKKGTKFH QSIGKHYSSG YGQGDVLGFY INLPEDTETA 360
KSLPDTYKDK ALIKFKSYLY FEEKDFVDKA EKSLKQTPHS EIIFYKNGVN QGVAYKDIFE 420
GVYFPAISLY KSCTVSINFG PCFKYPPKDL TYRPMSDMGW GAVVEHTLAD VLYHVETEVD 480
GRRSPPWEP 489 
Gene Ontology
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF00622; SPRY 
SMART
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY 
PRINTS