UniProt Accession

 Q5LJA9_HUMAN; Q5LJA9 

Genbank Protein ID

 AL136370 

Genbank Nucleotide ID

  

Protein Name

 Ubiquitin carboxyl-terminal hydrolase isozyme L5 

Protein Synonyms/Alias

  

Gene Name

 UCHL5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
166	QMFEFDTKTSAKEED	ubiquitination	[1]
170	FDTKTSAKEEDAFHF	acetylation	[2]
170	FDTKTSAKEEDAFHF	ubiquitination	[1]
222	VIEKRIQKDGFSPCC	ubiquitination	[3]
239	WSQTPELKPSACLDL	ubiquitination	[3]
273	RKMIYEQKIAELQRQ	ubiquitination	[1]
354	QLIPLVEKAKEKQNA	ubiquitination	[1, 3]
356	IPLVEKAKEKQNAKK	ubiquitination	[3]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 368 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008242; F:omega peptidase activity; IEA:InterPro.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 

Interpro

 IPR001578; Peptidase_C12.
 IPR017390; Ubiquitinyl_hydrolase_UCH37. 

Pfam

 PF01088; Peptidase_C12 

SMART

  

PROSITE

  

PRINTS

 PR00707; UBCTHYDRLASE.