CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003904
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysosome-associated membrane glycoprotein 1 
Protein Synonyms/Alias
 LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; CD107a 
Gene Name
 LAMP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
319DARDPAFKAANGSLRubiquitination[1]
337ATVGNSYKCNAEEHVubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. 
Sequence Annotation
 REGION 29 194 First lumenal domain.
 REGION 195 227 Hinge.
 REGION 228 382 Second lumenal domain.
 CARBOHYD 37 37 N-linked (GlcNAc...).
 CARBOHYD 45 45 N-linked (GlcNAc...).
 CARBOHYD 62 62 N-linked (GlcNAc...)
 CARBOHYD 76 76 N-linked (GlcNAc...).
 CARBOHYD 84 84 N-linked (GlcNAc...).
 CARBOHYD 103 103 N-linked (GlcNAc...).
 CARBOHYD 107 107 N-linked (GlcNAc...).
 CARBOHYD 121 121 N-linked (GlcNAc...)
 CARBOHYD 130 130 N-linked (GlcNAc...)
 CARBOHYD 165 165 N-linked (GlcNAc...).
 CARBOHYD 181 181 N-linked (GlcNAc...).
 CARBOHYD 197 197 O-linked (GalNAc...); partial.
 CARBOHYD 199 199 O-linked (GalNAc...).
 CARBOHYD 200 200 O-linked (GalNAc...).
 CARBOHYD 207 207 O-linked (GalNAc...).
 CARBOHYD 209 209 O-linked (GalNAc...).
 CARBOHYD 211 211 O-linked (GalNAc...).
 CARBOHYD 223 223 N-linked (GlcNAc...)
 CARBOHYD 228 228 N-linked (GlcNAc...)
 CARBOHYD 241 241 N-linked (GlcNAc...).
 CARBOHYD 249 249 N-linked (GlcNAc...).
 CARBOHYD 261 261 N-linked (GlcNAc...).
 CARBOHYD 293 293 N-linked (GlcNAc...).
 CARBOHYD 322 322 N-linked (GlcNAc...).
 DISULFID 41 80
 DISULFID 155 191
 DISULFID 231 269
 DISULFID 338 375  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Endosome; Glycoprotein; Lysosome; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 417 AA 
Protein Sequence
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP 60
KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY 120
NLSDTHLFPN ASSKEIKTVE SITDIRADID KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS 180
NSSFSRGETR CEQDRPSPTT APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL 240
NLTYERKDNT TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF 300
LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF SVNIFKVWVQ 360
AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL IAYLVGRKRS HAGYQTI 417 
Gene Ontology
 GO:0097208; C:alveolar lamellar body; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005770; C:late endosome; IDA:UniProtKB.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0042470; C:melanosome; IEA:Compara.
 GO:0005771; C:multivesicular body; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0048102; P:autophagic cell death; IEA:Compara.
 GO:0006914; P:autophagy; IEA:Compara. 
Interpro
 IPR018134; LAMP_CS.
 IPR002000; Lysosome-assoc_membr_glycop. 
Pfam
 PF01299; Lamp 
SMART
  
PROSITE
 PS00310; LAMP_1
 PS00311; LAMP_2
 PS51407; LAMP_3 
PRINTS
 PR00336; LYSASSOCTDMP.