UniProt Accession

 B4DX30_HUMAN; B4DX30 

Genbank Protein ID

 AL157786; AK301786 

Genbank Nucleotide ID

 BAG63242.1 

Protein Name

 Long-chain-fatty-acid--CoA ligase 5 

Protein Synonyms/Alias

 cDNA FLJ52792, highly similar to Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) 

Gene Name

 ACSL5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
123	RLLADDMKTLKPTLF	ubiquitination	[1]
126	ADDMKTLKPTLFPAV	ubiquitination	[1, 2]
143	LLNRIYDKVQNEAKT	ubiquitination	[1]
186	WDKLIFAKIQDSLGG	ubiquitination	[1, 2, 3]
288	NVFKGYLKDPEKTQE	ubiquitination	[1, 2]
339	GEYIAPEKIENIYNR	ubiquitination	[2]
381	VLPSFAAKLGVKGSF	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Ligase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 465 AA 

Protein Sequence

Gene Ontology

 GO:0016874; F:ligase activity; IEA:UniProtKB-KW. 

Interpro

 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 

Pfam

 PF00501; AMP-binding 

SMART

  

PROSITE

 PS00455; AMP_BINDING 

PRINTS