UniProt Accession

 TBC20_HUMAN; Q96BZ9; A8K6I3; Q5JWQ7; Q6ZSY8; Q96NE1; Q9BYM7; Q9H140 

Genbank Protein ID

 AK055573; AK127062; AK291648; AL121747; AL049761; AL049761; AL121747; CH471133; BC014983 

Genbank Nucleotide ID

 BAC86808.1; BAF84337.1; CAI23015.1; CAI23015.1; CAI23048.1; CAI23048.1; EAX10670.1 

Protein Name

 TBC1 domain family member 20 

Protein Synonyms/Alias

  

Gene Name

 TBC1D20 

Gene Synonyms/Alias

 C20orf140 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	DPPPISGKNLRQMSK	ubiquitination	[1, 2]
326	RTAASTFKDFELASA	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May act as a GTPase-activating protein for Rab family protein(s). 

Sequence Annotation

 DOMAIN 60 246 Rab-GAP TBC.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; GTPase activation; Host-virus interaction; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 403 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR000195; Rab-GTPase-TBC_dom. 

Pfam

 PF00566; RabGAP-TBC 

SMART

 SM00164; TBC 

PROSITE

 PS50086; TBC_RABGAP 

PRINTS