| Tag | Content |
|---|
| CPLM ID | CPLM-011298 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sphingosine-1-phosphate lyase |
Protein Synonyms/Alias | S1PL; SP-lyase; ySPL; Bestowed of sphingosine tolerance 1; Sphingosine-1-phosphate aldolase |
Gene Name | DPL1 |
Gene Synonyms/Alias | BST1; YDR294C; D9819.5 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 380 | SISCDTHKYGFAPKG | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. |
Sequence Annotation | MOD_RES 380 380 N6-(pyridoxal phosphate)lysine (By |
Keyword | 3D-structure; Complete proteome; Lipid metabolism; Lyase; Pyridoxal phosphate; Reference proteome; Sphingolipid metabolism. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 589 AA |
Protein Sequence | MSGVSNKTVS INGWYGMPIH LLREEGDFAQ FMILTINELK IAIHGYLRNT PWYNMLKDYL 60
FVIFCYKLIS NFFYLLKVYG PVRLAVRTYE HSSRRLFRWL LDSPFLRGTV EKEVTKVKQS 120
IEDELIRSDS QLMNFPQLPS NGIPQDDVIE ELNKLNDLIP HTQWKEGKVS GAVYHGGDDL 180
IHLQTIAYEK YCVANQLHPD VFPAVRKMES EVVSMVLRMF NAPSDTGCGT TTSGGTESLL 240
LACLSAKMYA LHHRGITEPE IIAPVTAHAG FDKAAYYFGM KLRHVELDPT TYQVDLGKVK 300
KFINKNTILL VGSAPNFPHG IADDIEGLGK IAQKYKLPLH VDSCLGSFIV SFMEKAGYKN 360
LPLLDFRVPG VTSISCDTHK YGFAPKGSSV IMYRNSDLRM HQYYVNPAWT GGLYGSPTLA 420
GSRPGAIVVG CWATMVNMGE NGYIESCQEI VGAAMKFKKY IQENIPDLNI MGNPRYSVIS 480
FSSKTLNIHE LSDRLSKKGW HFNALQKPVA LHMAFTRLSA HVVDEICDIL RTTVQELKSE 540
SNSKPSPDGT SALYGVAGSV KTAGVADKLI VGFLDALYKL GPGEDTATK 589 |
Gene Ontology | GO:0032541; C:cortical endoplasmic reticulum; IDA:SGD. GO:0097038; C:perinuclear endoplasmic reticulum; IDA:SGD. GO:0016831; F:carboxy-lyase activity; IEA:InterPro. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0008117; F:sphinganine-1-phosphate aldolase activity; IDA:SGD. GO:0019722; P:calcium-mediated signaling; IMP:SGD. GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro. GO:0009267; P:cellular response to starvation; IMP:SGD. GO:0006665; P:sphingolipid metabolic process; IGI:SGD. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |