UniProt Accession

 MLRS_MOUSE; P97457 

Genbank Protein ID

 U77943; BC055869 

Genbank Nucleotide ID

 AAB19118.1; AAH55869.1 

Protein Name

 Myosin regulatory light chain 2, skeletal muscle isoform 

Protein Synonyms/Alias

 Fast skeletal myosin light chain 2; MLC2F 

Gene Name

 Mylpf 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
47	NRDGIIDKEDLRDTF	ubiquitination	[1]
63	AMGRLNVKNEELDAM	ubiquitination	[1]
92	TMFGEKLKGADPEDV	acetylation	[2]
92	TMFGEKLKGADPEDV	ubiquitination	[1]
105	DVITGAFKVLDPEGK	acetylation	[2]
105	DVITGAFKVLDPEGK	ubiquitination	[1]
112	KVLDPEGKGTIKKQF	acetylation	[2]
112	KVLDPEGKGTIKKQF	ubiquitination	[1]
116	PEGKGTIKKQFLEEL	ubiquitination	[1]
117	EGKGTIKKQFLEELL	ubiquitination	[1]
166	VITHGDAKDQE****	acetylation	[2]
166	VITHGDAKDQE****	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

  

Sequence Annotation

 DOMAIN 25 60 EF-hand 1.
 DOMAIN 95 130 EF-hand 2.
 DOMAIN 131 166 EF-hand 3.
 MOD_RES 2 2 N,N,N-trimethylalanine (By similarity).
 MOD_RES 16 16 Phosphoserine.  

Keyword

 Calcium; Complete proteome; Metal-binding; Methylation; Motor protein; Muscle protein; Myosin; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008307; F:structural constituent of muscle; IMP:BHF-UCL.
 GO:0006955; P:immune response; IEA:Compara.
 GO:0007519; P:skeletal muscle tissue development; IMP:BHF-UCL. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13405; EF_hand_4 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS