CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031426
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Origin recognition complex subunit 3 
Protein Synonyms/Alias
 cDNA FLJ59790, highly similar to Origin recognition complex subunit 3 
Gene Name
 ORC3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92AKDCPDMKHFLQKLIacetylation[1]
112CCVDIKSKEEESVHVubiquitination[2, 3]
330VEKQASEKQVALLTNubiquitination[2]
375KFTSSLPKYPLGRQIubiquitination[2, 3, 4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 444 AA 
Protein Sequence
MKSENERLQE ELNKNLFDNL IEFLQKSHSG FQKNSRDLGG QIKLREIPTA ALVLGVNVTD 60
HDLTFGSLTE ALQNNVTPYV VSLQAKDCPD MKHFLQKLIS QLMDCCVDIK SKEEESVHVT 120
QRKTHYSMDS LSSWYMTVTQ KTDPKMLSKK RTTSSQWQSP PVVVILKDME SFATKVLQDF 180
IIISSQHLHE FPLILIFGIA TSPIIIHRLL PHAVSSLLCI ELFQSLSCKE HLTTVLDKLL 240
LTTQFPFKIN EKVLQVLTNI FLYHDFSVQN FIKGLQLSLL EHFYSQPLSV LCCNLPEAKR 300
RINFLSNNQC ENIRRLPSFR RYVEKQASEK QVALLTNERY LKEETQLLLE NLHVYHMNYF 360
LVLRCLHKFT SSLPKYPLGR QIRELYCTCL EKNIWDSEEY ASVLQLLRLG LAFLDIQLFG 420
AQSGQELLLP LSWEANPSHA ANLG 444 
Gene Ontology
 GO:0005664; C:nuclear origin of replication recognition complex; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:InterPro. 
Interpro
 IPR020795; ORC3. 
Pfam
 PF07034; ORC3_N 
SMART
  
PROSITE
  
PRINTS