| Tag | Content |
|---|
| CPLM ID | CPLM-003778 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myb-related protein B |
Protein Synonyms/Alias | B-Myb; Myb-like protein 2 |
Gene Name | MYBL2 |
Gene Synonyms/Alias | BMYB |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 135 | HLNPEVKKSCWTEEE | ubiquitination | [1] | | 411 | GTPPSVLKRQRKRRV | ubiquitination | [1] | | 533 | LEKYGPLKPLPQTPH | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. |
Sequence Annotation | DOMAIN 26 77 HTH myb-type 1.
DOMAIN 78 133 HTH myb-type 2.
DOMAIN 134 184 HTH myb-type 3.
DNA_BIND 54 77 H-T-H motif (By similarity).
DNA_BIND 106 129 H-T-H motif (By similarity).
DNA_BIND 157 180 H-T-H motif (By similarity).
MOTIF 411 417 Nuclear localization signal.
MOTIF 564 584 Bipartite nuclear localization signal.
MOD_RES 241 241 Phosphoserine.
MOD_RES 266 266 Phosphothreonine.
MOD_RES 440 440 Phosphothreonine; by CDK2.
MOD_RES 444 444 Phosphothreonine; by CDK2.
MOD_RES 487 487 Phosphothreonine; by CDK2.
MOD_RES 494 494 Phosphothreonine; by CDK2.
MOD_RES 520 520 Phosphothreonine; by CDK2.
MOD_RES 577 577 Phosphoserine; by CDK2. |
Keyword | Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 700 AA |
Protein Sequence | MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEEDE QLRALVRQFG QQDWKFLASH 60
FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK YGTKQWTLIA KHLKGRLGKQ 120
CRERWHNHLN PEVKKSCWTE EEDRIICEAH KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI 180
KRKVDTGGFL SESKDCKPPV YLLLELEDKD GLQSAQPTEG QGSLLTNWPS VPPTIKEEEN 240
SEEELAAATT SKEQEPIGTD LDAVRTPEPL EEFPKREDQE GSPPETSLPY KWVVEAANLL 300
IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSAEDSI NNSLVQLQAS HQQQVLPPRQ 360
PSALVPSVTE YRLDGHTISD LSRSSRGELI PISPSTEVGG SGIGTPPSVL KRQRKRRVAL 420
SPVTENSTSL SFLDSCNSLT PKSTPVKTLP FSPSQFLNFW NKQDTLELES PSLTSTPVCS 480
QKVVVTTPLH RDKTPLHQKH AAFVTPDQKY SMDNTPHTPT PFKNALEKYG PLKPLPQTPH 540
LEEDLKEVLR SEAGIELIIE DDIRPEKQKR KPGLRRSPIK KVRKSLALDI VDEDVKLMMS 600
TLPKSLSLPT TAPSNSSSLT LSGIKEDNSL LNQGFLQAKP EKAAVAQKPR SHFTTPAPMS 660
SAWKTVACGG TRDQLFMQEK ARQLLGRLKP SHTSRTLILS 700 |
Gene Ontology | GO:0031523; C:Myb complex; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003682; F:chromatin binding; IEA:InterPro. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0000278; P:mitotic cell cycle; TAS:Reactome. GO:0090307; P:spindle assembly involved in mitosis; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |