CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037472
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kinase D-interacting substrate of 220 kDa 
Protein Synonyms/Alias
  
Gene Name
 KIDINS220 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
292IVRALLQKYADIDIRubiquitination[1, 2]
417NIDCSHQKSILTQIFubiquitination[3, 4]
592ELPEQTTKALPVRFLubiquitination[2]
642TRLFRVFKTEDTQGKubiquitination[4]
738ASKLHKLKSEGFMKVubiquitination[2, 4]
747EGFMKVLKCEVELMAubiquitination[4]
855RGLSNARKFLVTSATubiquitination[4]
892NSLGEMTKLGSKTALubiquitination[1, 2, 3, 4, 5]
896EMTKLGSKTALNRRDubiquitination[2]
1008TIYERISKNIPTTKDubiquitination[4]
1058CTVNLDPKLREIIADubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1305 AA 
Protein Sequence
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN LEIVKELIKN 60
GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR DMGGWTALMW ACYKGRTDVV 120
ELLLSHGANP SVTGLQYSVY PIIWAAGRGH ADIVHLLLQN GAKVNCSDKY GTTPLVWAAR 180
KGHLECVKHL LAMGADVDQE GANSMTALIV AVKGGYTQSV KEILKRNPNV NLTDKDGNTA 240
LMIASKEGHT EIVQDLLDAG TYVNIPDRSG DTVLIGAVRG GHVEIVRALL QKYADIDIRG 300
QDNKTALYWA VEKGNATMVR DILQCNPDTE ICTKDGETPL IKATKMRNIE VVELLLDKGA 360
KVSAVDKKGD TPLHIAIRGR SRKLAELLLR NPKDGRLLYR PNKAGETPYN IDCSHQKSIL 420
TQIFGARHLS PTETDGDMLG YDLYSSALAD ILSEPTMQPP ICVGLYAQWG SGKSFLLKKL 480
EDEMKTFAGQ QIEPLFQFSW LIVFLTLLLC GGLGLLFAFT VHPNLGIAVS LSFLALLYIF 540
FIVIYFGGRR EGESWNWAWV LSTRLARHIG YLELLLKLMF VNPPELPEQT TKALPVRFLF 600
TDYNRLSSVG GETSLAEMIA TLSDACEREF GFLATRLFRV FKTEDTQGKK KWKKTCCLPS 660
FVIFLFIIGC IISGITLLAI FRVDPKHLTV NAVLISIASV VGLAFVLNCR TWWQVLDSLL 720
NSQRKRLHNA ASKLHKLKSE GFMKVLKCEV ELMARMAKTI DSFTQNQTRL VVIIDGLDAC 780
EQDKVLQMLD TVRVLFSKGP FIAIFASDPH IIIKAINQNL NSVLRDSNIN GHDYMRNIVH 840
LPVFLNSRGL SNARKFLVTS ATNGDVPCSD TTGIQEDADR RVSQNSLGEM TKLGSKTALN 900
RRDTYRRRQM QRTITRQMSF DLTKLLVTED WFSDISPQTM RRLLNIVSVT GRLLRANQIS 960
FNWDRLASWI NLTEQWPYRT SWLILYLEET EGIPDQMTLK TIYERISKNI PTTKDVEPLL 1020
EIDGDIRNFE VFLSSRTPVL VARDVKVFLP CTVNLDPKLR EIIADVRAAR EQISIGGLAY 1080
PPLPLHEGPP RAPSGYSQPP SVCSSTSFNG PFAGGVVSPQ PHSSYYSGMT GPQHPFYNRG 1140
SGPAPGPVVL LNSLNVDAVC EKLKQIEGLD QSMLPQYCTT IKKANINGRV LAQCNIDELK 1200
KEMNMNFGDW HLFRSTVLEM RNAESHVVPE DPRFLSESSS GPAPHGEPAR RASHNELPHT 1260
ELSSQTPYTL NFSFEELNTL GLDEGAPRHS NLSWQSQTRR TPSLS 1305 
Gene Ontology
  
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011646; KAP_NTPase.
 IPR013761; SAM/pointed. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF07693; KAP_NTPase 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS
 PR01415; ANKYRIN.