CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042336
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Vigilin 
Protein Synonyms/Alias
  
Gene Name
 HDLBP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
109VERLEVEKAFHPFIAubiquitination[1, 2]
152EIVFTGEKEQLAQAVubiquitination[2]
303PQGVQQAKRELLELAubiquitination[2, 3]
701HRSVMGPKGSRIQQImethylation[4]
768IISGRKEKCEAAKEAacetylation[5]
840AANLDRAKAGLLERVubiquitination[2]
848AGLLERVKELQAEQEubiquitination[2]
871LSVTVDPKYHPKIIGacetylation[6]
945WTASSSEKAPDMSSSubiquitination[7]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [5] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [7] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 973 AA 
Protein Sequence
XGLSIMVSGK LDAVMKARKD IVARLQTQAS ATVAIPKEHH RFVIGKNGEK LQDLELKTAT 60
KIQIPRPDDP SNQIKITGTK EGIEKARHEV LLISAEQDKR AVERLEVEKA FHPFIAGPYN 120
RLVGEIMQET GTRINIPPPS VNRTEIVFTG EKEQLAQAVA RIKKIYEEKA NSFTVSSVAA 180
PSWLHRFIIG KKGQNLAKIT QQMPKVHIEF TEGEDKITLE GPTEDVNVAQ EQIEGMVKDL 240
INRMDYVEIN IDHKFHRHLI GKSGANINRI KDQYKVSVRI PPDSEKSNLI RIEGDPQGVQ 300
QAKRELLELA SRMENERTKD LIIEQRFHRT IIGQKGERIR EIRDKFPEVI INFPDPAQKS 360
DIVQLRGPKN EVEKCTKYMQ KMVADLVENS YSISVPIFKQ FHKNIIGKGG ANIKKIREES 420
NTKIDLPAEN SNSETIIITG KRANCEAARS RILSIQKDLA NIAEVEVSIP AKLHNSLIGT 480
KGRLIRSIME ECGGVHIHFP VEGSGSDTVV IRGPSSDVEK AKKQLLHLAE EKQTKSFTVD 540
IRAKPEYHKF LIGKGGGKIR KVRDSTGARV IFPAAEDKDQ DLITIIGKED AVREAQKELE 600
ALIQNLDNVV EDSMLVDPKH HRHFVIRRGQ VLREIAEEYG GVMVSFPRSG TQSDKVTLKG 660
AKDCVEAAKK RIQEIIEDLE AQVTLECAIP QKFHRSVMGP KGSRIQQITR DFSVQIKFPD 720
REENAVHSTE PVVQENGDEA GEGREAKDCD PGSPRRCDII IISGRKEKCE AAKEALEALV 780
PVTIEVEVPF DLHRYVIGQK GSGIRKMMDE FEVNIHVPAP ELQSDIIAIT GLAANLDRAK 840
AGLLERVKEL QAEQEDRALR SFKLSVTVDP KYHPKIIGRK GAVITQIRLE HDVNILNLEE 900
EYLADVVDSE ALQVYMKPPA HEEAKAPSRG FVVRDAPWTA SSSEKAPDMS SSEEFPSFGA 960
QVAPKTLPWG PKR 973 
Gene Ontology
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 
Pfam
 PF00013; KH_1 
SMART
 SM00322; KH 
PROSITE
 PS50084; KH_TYPE_1 
PRINTS