| Tag | Content |
|---|
| CPLM ID | CPLM-019454 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-box/LRR-repeat protein 18 |
Protein Synonyms/Alias | F-box and leucine-rich repeat protein 18 |
Gene Name | FBXL18 |
Gene Synonyms/Alias | FBL18 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 84 | DYQASEDKVRQLVKE | ubiquitination | [1] | | 90 | DKVRQLVKEIGREIQ | ubiquitination | [1] | | 138 | LTSLRLSKMLSALQH | ubiquitination | [1] | | 167 | SQLSSECKATLSRVR | ubiquitination | [1] | | 177 | LSRVRELKQTLFTPS | ubiquitination | [1] | | 340 | QQVINGGKDLRSLAS | ubiquitination | [1] | | 365 | SPDSLLRKAEDDIDS | ubiquitination | [1] | | 706 | LDEITLFKSRVAEEP | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity). |
Sequence Annotation | DOMAIN 25 72 F-box.
REPEAT 77 103 LRR 1.
REPEAT 104 128 LRR 2.
REPEAT 129 153 LRR 3.
REPEAT 177 201 LRR 4.
REPEAT 324 352 LRR 5.
REPEAT 367 392 LRR 6.
REPEAT 393 422 LRR 7.
REPEAT 468 492 LRR 8.
REPEAT 516 540 LRR 9.
REPEAT 542 567 LRR 10.
REPEAT 572 597 LRR 11.
REPEAT 599 623 LRR 12. |
Keyword | Alternative splicing; Complete proteome; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 805 AA |
Protein Sequence | MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL NVRRTCRKLA 60
ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS MAGCYWLPGS TVEHVARCRS 120
LVKVNLSGCH LTSLRLSKML SALQHLRSLA IDVSPGFDAS QLSSECKATL SRVRELKQTL 180
FTPSYGVVPC CTSLEKLLLY FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG 240
YINQEVVRLY LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS 300
WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL SGCVHCLSPD 360
SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG LGRHLCQLLA RLRHLRSLSL 420
PVCSVADSAP RADRAPAQPA MHAVPRGFGK KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK 480
NLPFLEHLEL IGSNFSSAMP RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ 540
LPSVLTGSGL VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF 600
SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT GESLATCKSL 660
QQSLLRSFQA ERPALNVVIF PLLHEGLTDV IRDVPLVHLD EITLFKSRVA EEPPNLWW 718 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |