CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003962
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2D9 
Protein Synonyms/Alias
 CYPIID9; Cytochrome P450-16-alpha; Cytochrome P450CA; Testosterone 16-alpha hydroxylase 
Gene Name
 Cyp2d9 
Gene Synonyms/Alias
 Cyp2d-9 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
150RNFGLGKKSLEDWVTubiquitination[1]
242RIPRLADKALQGQKSubiquitination[1]
248DKALQGQKSFIAILDubiquitination[1]
284AFLAEIEKAKGNPESubiquitination[1]
286LAEIEKAKGNPESSFubiquitination[1]
394VQDFLIPKGTILLPNubiquitination[1]
407PNMSSMLKDESVWEKubiquitination[1]
414KDESVWEKPLRFHPEubiquitination[1]
432DAQGHFVKPEAFMPFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 446 446 Iron (heme axial ligand).
 MOD_RES 138 138 Phosphoserine.  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MELLTGTDLW PVAIFTVIFI LLVDLTHQRQ RWTSRYPPGP VPWPVLGNLL QVDLGNMPYS 60
LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED TADRPPVPIF EYLGVKPGSQ 120
GVVLAPYGPE WREQRRFSVS TLRNFGLGKK SLEDWVTKEA NHLCDAFTAQ AGQPINPNPM 180
LNKSTCNVIA SLIFARRFEY EDPFLIRMLK VLEQSLTEVS GLIPEVLNAF PILLRIPRLA 240
DKALQGQKSF IAILDNLLTE NRTTWDPVQA PRNLTDAFLA EIEKAKGNPE SSFNDENLLM 300
VVRDLFGAGM LTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVRHPEM ADQAHMPYTN 360
AVIHEVQRFG DIVPVNLPRI TSHDIEVQDF LIPKGTILLP NMSSMLKDES VWEKPLRFHP 420
EHFLDAQGHF VKPEAFMPFS AGRRSCLGEA LARMELFLFF TCLLQRFSFS VPDGQPQPSN 480
SGVYGILVAP SPYQLCAVVR DQGH 504 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.