CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038802
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ras-specific guanine nucleotide-releasing factor 1 
Protein Synonyms/Alias
  
Gene Name
 Rasgrf1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
158ETEKTVAKQLRQQLEubiquitination[1]
204EDEDSDIKKIKKVQSubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Guanine-nucleotide releasing factor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1246 AA 
Protein Sequence
MQKAIRLNDG HVVSLGLLAQ RDGTRKGYLS KRSSDNPKWQ TKWFALLQNL LFYFESDSSS 60
HQEGLMWMEA SLPSRGPTPK TRGAKGHSAV QHHYFTVNFS NDSQKSLELR TDDSKDCDEW 120
VAAIARASYK ILATEHEALM QKYLHLLQVV ETEKTVAKQL RQQLEDGEVE IERLKAEIAN 180
LIKDNERIQS NQLVAPEDED SDIKKIKKVQ SFLRGWLCRR KWKNIIQDYI RSPHADSMRK 240
RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 300
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL 360
KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS 420
RVMHDEVSET ENIRKNLAIE RMITEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKINKGRLG 480
SLSLKKEGER QCFLFSKHLI ICTRGSGSKL HLTKNGVISL IDCTLLDDPE NMDDDGKGKG 540
QEVDHLDFKI WVEPKDSPPF TVILVASSRQ EKAAWTSDII QCVDNIRCNG LMMNAFEENS 600
KVTVPQMIKS DASLYCDDVD IRFSKTMNSC KVLQIRYASV ERLLERLTDL RFLSIDFLNT 660
FLHSYRVFTD AVVVLDKLIS IYKKPITAIP ARSLELLFSS SHNTKLLYGD APKSPRASRK 720
FSSPPPLAIG TSSPVRRRKL SLNIPIITGG KALELASLGC PSDGYTNIHS PISPFGKTTL 780
DTSKLCVASS LTRTPEEIDM TTLEESSGFR KPTSDILKEE SDDDQSDVDD TEVSPPTPKS 840
FRNRITQEFP LFNYNSGIMM TCRDLMDSNR SPLSATSAFA IATAGANESP ANKEIYRRMS 900
LANTGYSSDQ RNIDKEFVIR RAATNRVLNV LRHWVTKHSQ DFETDDLLKY KVICFLEEVM 960
HDPDLLPQER KAAANIMRTL TQEEITENHS MLDELLLMTE GVKTEPFENH SAMEIAEQLT 1020
LLDHLVFKSI PYEEFFGQGW MKADKNERTP YIMKTTRHFN HISNLIASEI LRNEEVSARA 1080
STIEKWVAVA DICRCLHNYN AVLEITSSIN RSAIFRLKKT WLKVSKQTKS LFDKLQKLVS 1140
SDGRFKNLRE TLRNCDPPCV PYLGMYLTDL AFLEEGTPNY TEDGLVNFSK MRMISHIIRE 1200
IRQFQQTTYK IEPQPKVTQY LVDETFVLDD ESLYEASLRI EPKLPT 1246 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR019804; Ras_G-nucl-exch_fac_CS.
 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25. 
Pfam
 PF00169; PH
 PF00617; RasGEF
 PF00618; RasGEF_N
 PF00621; RhoGEF 
SMART
 SM00015; IQ
 SM00233; PH
 SM00147; RasGEF
 SM00229; RasGEFN
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS50096; IQ
 PS50003; PH_DOMAIN
 PS00720; RASGEF
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER 
PRINTS