| Tag | Content |
|---|
| CPLM ID | CPLM-019620 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribosomal protein S6 kinase delta-1 |
Protein Synonyms/Alias | S6K-delta-1; 52 kDa ribosomal protein S6 kinase; Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein; SPHK1-binding protein |
Gene Name | RPS6KC1 |
Gene Synonyms/Alias | RPK118 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 651 | SFNTSESKVEFKAQD | ubiquitination | [1] | | 674 | SVPVISFKDAAFDDV | ubiquitination | [1] | | 759 | LSDPSGPKSYSITEK | ubiquitination | [1] | | 869 | FQRDSETKGESGLVL | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. |
Sequence Annotation | DOMAIN 8 132 PX.
DOMAIN 277 305 MIT.
DOMAIN 344 445 Protein kinase 1.
DOMAIN 794 1056 Protein kinase 2.
NP_BIND 801 809 ATP (By similarity).
ACT_SITE 929 929 Proton acceptor (By similarity).
BINDING 820 820 ATP (By similarity).
MOD_RES 423 423 Phosphoserine.
MOD_RES 427 427 Phosphoserine.
MOD_RES 583 583 Phosphoserine (By similarity).
MOD_RES 640 640 Phosphoserine (By similarity). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1066 AA |
Protein Sequence | MTSYRERSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV WKRYSDFKKL 60
HKELWQIHKN LFRHSELFPP FAKGIVFGRF DETVIEERRQ CAEDLLQFSA NIPALYNSKQ 120
LEDFFKGGII NDSSELIGPA EAHSDSLIDT FPECSTEGFS SDSDLVSLTV DVDSLAELDD 180
GMASNQNSPI RTFGLNLSSD SSALGAVASD SEQSKTEEER ESRSLFPGSL KPKLGKRDYL 240
EKAGELIKLA LKKEEEDDYE AASDFYRKGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA 300
ESISSLYGKP QLDDVSQPPG SLSSRPLWNL RSPAEELKAF RVLGVIDKVL LVMDTRTEQT 360
FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV FLVLQHAEGG KLWSYISKFL 420
NRSPEESFDI KEVKKPTLAK VHLQQPTSSP QDSSSFESRG SDGGSMLKAL PLKSSLTPSS 480
QDDSNQEDDG QDSSPKWPDS GSSSEEECTT SYLTLCNEYG QEKIEPGSLN EEPFMKTEGN 540
GVDTKAIKSF PAHLAADSDS PSTQLRAHEL KFFPNDDPEA VSSPRTSDSL SRSKNSPMEF 600
FRIDSKDSAS ELLGLDFGEK LYSLKSEPLK PFFTLPDGDS ASRSFNTSES KVEFKAQDTI 660
SRGSDDSVPV ISFKDAAFDD VSGTDEGRPD LLVNLPGELE STREAAAMGP TKFTQTNIGI 720
IENKLLEAPD VLCLRLSTEQ CQAHEEKGIE ELSDPSGPKS YSITEKHYAQ EDPRMLFVAA 780
VDHSSSGDMS LLPSSDPKFQ GLGVVESAVT ANNTEESLFR ICSPLSGANE YIASTDTLKT 840
EEVLLFTDQT DDLAKEEPTS LFQRDSETKG ESGLVLEGDK EIHQIFEDLD KKLALASRFY 900
IPEGCIQRWA AEMVVALDAL HREGIVCRDL NPNNILLNDR GHIQLTYFSR WSEVEDSCDS 960
DAIERMYCAP EVGAITEETE ACDWWSLGAV LFELLTGKTL VECHPAGINT HTTLNMPECV 1020
SEEARSLIQQ LLQFNPLERL GAGVAGVEDI KSHPFFTPVD WAELMR 1066 |
Gene Ontology | GO:0005769; C:early endosome; IDA:UniProtKB. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0035091; F:phosphatidylinositol binding; IEA:InterPro. GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc. GO:0007165; P:signal transduction; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |