CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016252
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rotatin 
Protein Synonyms/Alias
  
Gene Name
 RTTN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
171NQTVKCLKFSTFPWLubiquitination[1]
617LLQGESQKVLLHMLSubiquitination[1]
767MLRLLLVKKPSVRSLubiquitination[1]
792SEEGADTKRPLIDARubiquitination[1]
811VTDLFIGKKPIELRLacetylation[2]
811VTDLFIGKKPIELRLubiquitination[1]
812TDLFIGKKPIELRLDubiquitination[1]
849DVDLVLRKSAAEQLAubiquitination[1]
1107LNDRLSLKGCPGPCGubiquitination[1]
1528NGLDDSFKFWRAPSRubiquitination[1, 3]
1852ILQCYEGKSSKDILKubiquitination[1]
1855CYEGKSSKDILKRVAubiquitination[1]
1882RAQKHALKANLIDNCubiquitination[1]
1909LDSLRPGKAALKKKEubiquitination[1]
1913RPGKAALKKKEDGVIubiquitination[1]
2198EAYSLAKKTFPNSEAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2. 
Sequence Annotation
 MOD_RES 811 811 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Disease mutation; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2226 AA 
Protein Sequence
MVLAGLIRKL GHQLAEIRER ALKSILCKIE HNLICYADLI QERQLFLHLL EWFNFPSVPM 60
KEEVLNLLSR LVKYPPAVQH LVDVGAVEFL SKLRSNVEPN LQAEIDGILD GLFLLPSEVP 120
ALSSASYQTN QTELSKNPEI LTGYFPQDKS NFQQMEVPPR PVVNQTVKCL KFSTFPWLPL 180
TTTDRHVLSS NESSLRSSNH TLIWNTCELL KDVIMQDFPA EIFLQRPKIV QSLLSLLKLA 240
FGDGKHRLAL QSVSCLQQLC MYLRNRLNFH RDPGFFSNKH DTVSQNSSLS YCHEARGTHH 300
SQNPSPGSSS PRPSVVGRTG QRPRGDGQDW DAASSSGSSS HAHVNSRISV HSPLDMGHID 360
LPELETEDTL ELQFQQLSLP QFCVSILESA VPLLRTGSRQ VIIRVLELLT EDMTLIGEAI 420
STDIWDDSSL FGIDMKEKLL LVLGALGETM CYHKSSISLE QPEVMLVHHR MAFISISLFA 480
VRLLQTLLPV EKASEFLSEP MSTALFLLSL DMPISLEYPN IHEAVVAYLE QLNSENYSIY 540
KRTAEAVYSI ECTCNFLSDI GKEGEKNLLE LVELADQALR SFSYHQHFPL IKEIISICSK 600
IWKSAQASPL LQGESQKVLL HMLSHPLPRV KAETYHCCLE ITKECLGVHN VTKPVSSLCN 660
GIHFLLHPKV LYEISVFGIQ EPESEVNTAA KAILLYLLQG RLMMTALTWN KFIESLCPVI 720
PILQGYADTE DPLGNCILLL SKASSDTEEM LPCTTRLKSM LRLLLVKKPS VRSLALKLLA 780
FHLTSEEGAD TKRPLIDARV LSRVTDLFIG KKPIELRLDD RRELVIKLET VEKVYEIFTS 840
DDVDLVLRKS AAEQLAVIMQ DIKMHAVVKK LCLIDKIIEY LNECVSQDGK VVECLVQPCL 900
TLLRKVLCGD PVMRVSLSQQ SSLLTVLFRV SLIFHEDCSV VTEVGALFCL LLFDEVSRMD 960
MWSVNPSNKP SLPSVFSLPV SVFRRYHLPV HVIGHHAVSP YSIVLPLSAD CLALKPVSDM 1020
LRIAWNLSWY HGSDNLLKQM NSETKTQEIL DALKLSTEDI LTLKITHMAS GLQDCLHSIV 1080
QAATHREVRA AVTRMSFYLL NDRLSLKGCP GPCGVTLKSL AWHTALNRFL QVLPACTEDE 1140
KLLIDIIHFL NKLIKEQRKN SSLELLNWIL ELLLRHSANP LLDLLVLTES QAREETDDIR 1200
TAVRQQLQKE LIALFDTLLL NFMEVTDRKC SELLYVFQTQ LALKLLQCLK VTDAPHFYGL 1260
PSLERTLRGM ANLTAFPGWS SHSPLTKPLD ICVKYLSGLL EVITSFYVER GGNAMSFMGK 1320
GVTKSTILCL LHLSHEMMAQ AGSLEWMSLW FLPLGSHSEE HIPTQQGLAW LIPLWVDRDP 1380
EVRFTSLGLG SALTTLETGC VALANSCQNI SGGLWGTVVN ILLDQSECSM VRREAAFILQ 1440
NLLVIPMPTE IIKDYTWQGP CVHDEDSGLS LIGKPALQAL LYHCHFYEHL NQMVKHCYLG 1500
RCMFDLNFSA FDRNSESNDL NGLDDSFKFW RAPSRTSQDR DPSSLSTSET TVAPSLGSTE 1560
FQPLVQSTTL LPEASHDQFV AQGHQESTSP RPPHDSSLSA PLPKLCVFVT PSLLSAMCSL 1620
LDNLLTIAPR DTAKAFRQAH LIELLCSIAD ATLIQTCVQE LRALLPSSPP AEHTQAQVSF 1680
LLEYLSSLSR LLQSCLLVEP DLVIQDELVK PLITNIIGIL TICTKDVLDK ELISAFYHTW 1740
THLFNLLAML LRKAGAITLP FVTVALAKHW TAAIDMFCTC AGLSATCPAL YTASLQFLSV 1800
LLTEEAKGHL QAKSKTHLCC SPTVASLLDD SQENQKSLEQ LSDVILQCYE GKSSKDILKR 1860
VAANALMSLL AVSRRAQKHA LKANLIDNCM EQMKHINAQL NLDSLRPGKA ALKKKEDGVI 1920
KELSIAMQLL RNCLYQNEEC KEAALEAHLV PVLHSLWPWI LMDDSLMQIS LQLLCVYTAN 1980
FPNGCSSLCW SSCGQHPVQA THRGAVSNSL MLCILKLASQ MPLENTTVQQ MVFMLLSNLA 2040
LSHDCKGVIQ KSNFLQNFLS LALPKGGNKH LSNLTILWLK LLLNISSGED GQQMILRLDG 2100
CLDLLTEMSK YKHKSSPLLP LLIFHNVCFS PANKPKILAN EKVITVLAAC LESENQNAQR 2160
IGAAALWALI YNYQKAKTAL KSPSVKRRVD EAYSLAKKTF PNSEANPLNA YYLKCLENLV 2220
QLLNSS 2226 
Gene Ontology
 GO:0036064; C:cilium basal body; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
  
SMART
  
PROSITE
  
PRINTS