| Tag | Content |
|---|
| CPLM ID | CPLM-011069 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase alpha |
Protein Synonyms/Alias | Protein-tyrosine phosphatase alpha; R-PTP-alpha |
Gene Name | Ptpra |
Gene Synonyms/Alias | Lrp |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 538 | FKKLTSIKIQNDKMR | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | |
Sequence Annotation | DOMAIN 235 495 Tyrosine-protein phosphatase 1.
DOMAIN 527 785 Tyrosine-protein phosphatase 2.
REGION 436 442 Substrate binding (By similarity).
ACT_SITE 436 436 Phosphocysteine intermediate (By
ACT_SITE 726 726 Phosphocysteine intermediate (By
BINDING 404 404 Substrate (By similarity).
BINDING 480 480 Substrate (By similarity).
MOD_RES 207 207 Phosphoserine (By similarity).
MOD_RES 792 792 Phosphotyrosine (By similarity).
CARBOHYD 20 20 N-linked (GlcNAc...) (Potential).
CARBOHYD 21 21 N-linked (GlcNAc...) (Potential).
CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).
CARBOHYD 51 51 N-linked (GlcNAc...) (Potential).
CARBOHYD 68 68 N-linked (GlcNAc...) (Potential).
CARBOHYD 80 80 N-linked (GlcNAc...) (Potential).
CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
CARBOHYD 127 127 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 796 AA |
Protein Sequence | MDSWFILILF GSGLIHISAN NTTTVSPSLG TTRLIKTSTT ESAKEENKTS NSTSSVISLS 60
VTPTFSPNLT LEPTYVTTVN SSHSDNGTKR AASTESGGTT ISPNGTYGTW LTDNQFTDAR 120
TEPWEGNSSS AATTPETFPP ADETPIIAVM VALSSLLVIL FIIIVLYMLR FKKYKQAGSH 180
SNSFRLSNGR TEDVEPQSVP LLARSPSTNR KYPPLPVDKL EEEINRRMAD DNKLFREEFN 240
ALPACPIQAT CEAASKEENK EKNRYVNLLP YDHSRVHLTP VEGVPDSDYI NASFINGYQE 300
KNKFIAAQGP KEETVNDFWR MIWEQNTATI VMVTNLKERK ECKCAQYWPD QGCWPYGNVR 360
VSVEDVTVLV DYTVRKFCIQ QVGDVTNRKP QRLITQFHFT SWPDFGVPFT PIGMLKFLKK 420
VKACNPQYAG AIVVHCSAGV GRTGTFVVID AMLDMMHSER KVDVYGFVSR IRAQRCQMVQ 480
TDMQYVFIYQ ALLEHYLYGD TELEVTSLDT HLQKIYNKIP GTSNNGLEEE FKKLTSIKIQ 540
NDKMRTGYLP ANMKKNRVLQ IIPYEFNRVI IPVKRGEENT DYVNASFIDP YRQKDSYIAS 600
QGPLLHTTED FWRMIWEWKS CSIVMLTELE ERGQEKCAQY WPSDGLVSYG DITVELKKEE 660
ECESYTVRDL LVTNTRENKS RQIRQFHFHG WPEVGIPSDG KGMINIIAAV QKQQQQSGNH 720
PITVHCSAGA GRTGTFCALS TVLECVKAEG ILDVFQTVKT LRLQRPHMVQ ILEQYEFCYK 780
VVQEYIDAFS DYANFK 796 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0005886; C:plasma membrane; IDA:RGD. GO:0032403; F:protein complex binding; IDA:RGD. GO:0004725; F:protein tyrosine phosphatase activity; IDA:RGD. GO:0048709; P:oligodendrocyte differentiation; IEP:RGD. GO:0048714; P:positive regulation of oligodendrocyte differentiation; IMP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |