CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035287
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Succinate-semialdehyde dehydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Aldh5a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
74YDPASGAKLGTVADCacetylation[1]
223VIPCSRTKAKEVGEVacetylation[1]
225PCSRTKAKEVGEVLCacetylation[1]
250TGSTATGKILLHHAAacetylation[1]
261HHAANSVKRVSMELGacetylation[1]
319IHDSFVTKFAEAMKKacetylation[1]
325TKFAEAMKKSLRVGNacetylation[1]
347QGPLINEKAVEKVEKacetylation[1]
351INEKAVEKVEKHVNDacetylation[1]
354KAVEKVEKHVNDAVAacetylation[1]
478GLGREGSKYGIDEYLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 495 AA 
Protein Sequence
MATCFLLRNF CAARPALRPP GRLLREPAGA QRRSYVGGPA DLHADLLRGD SFVGGRWLPT 60
PATFPVYDPA SGAKLGTVAD CGVPEARAAV RAAYDAFSSW KEISVKGKPL KEAQGEILYS 120
AFFLEWFSEE ARRVYGDIIY TSAKDKRGLV LKQPVGVASI ITPWNFPSAM ITRKVGAALA 180
AGCTVVVKPA EDTPYSALAL AQLANQAGIP PGVYNVIPCS RTKAKEVGEV LCTDPLVSKI 240
SFTGSTATGK ILLHHAANSV KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNAGQTC 300
VCSNRFLVQR GIHDSFVTKF AEAMKKSLRV GNGFEEGTTQ GPLINEKAVE KVEKHVNDAV 360
AKGATVVTGG KRHQSGGNFF EPTLLSNVTR DMLCITEETF GPLAPVIKFD KEEEAVAIAN 420
AADVGLAGYF YSQDPAQIWR VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG 480
IDEYLEVKYV CYGGL 495 
Gene Ontology
 GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
 GO:0009450; P:gamma-aminobutyric acid catabolic process; IEA:InterPro. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010102; Succ_semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS