UniProt Accession

 LYVE1_MOUSE; Q8BHC0; Q3TUC1; Q99NE4 

Genbank Protein ID

 AJ311501; AK004726; AK160857; BC038653; BC038892 

Genbank Nucleotide ID

 CAC33082.1; BAC25094.1; BAE36050.1; AAH38653.1; AAH38892.1 

Protein Name

 Lymphatic vessel endothelial hyaluronic acid receptor 1 

Protein Synonyms/Alias

 LYVE-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1 

Gene Name

 Lyve1 

Gene Synonyms/Alias

 Crsbp1; Xlkd1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
277	QKEMIETKVVKEEKA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. 

Sequence Annotation

 DOMAIN 39 129 Link.
 CARBOHYD 52 52 N-linked (GlcNAc...).
 CARBOHYD 129 129 N-linked (GlcNAc...) (Potential).
 DISULFID 60 127 By similarity.
 DISULFID 84 105 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005540; F:hyaluronic acid binding; IDA:MGI.
 GO:0004888; F:transmembrane signaling receptor activity; IDA:MGI.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0006027; P:glycosaminoglycan catabolic process; IDA:MGI.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR000538; Link. 

Pfam

 PF00193; Xlink 

SMART

 SM00445; LINK 

PROSITE

 PS01241; LINK_1
 PS50963; LINK_2 

PRINTS