CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027649
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heterogeneous nuclear ribonucleoprotein R 
Protein Synonyms/Alias
 Protein Hnrnpr 
Gene Name
 Hnrnpr 
Gene Synonyms/Alias
 Hnrpr 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
300FLEYEDHKSAAQARRacetylation[1]
366KSFSEFGKLERVKKLacetylation[1, 2]
366KSFSEFGKLERVKKLubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Ribonucleoprotein; Viral nucleoprotein; Virion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 632 AA 
Protein Sequence
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL 60
DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK 120
GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE 180
LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC 240
ISVANNRLFV GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK 300
SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT TVTEEILEKS 360
FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE GEEIEIVLAK PPDKKRKERQ 420
AARQASRSTA YEDYYYHPPP RMPPPMRGRG RGGRGGYGYP PDYYGYEDYY DDYYGYDYHD 480
YRGGYEDPYY GYDDGYAVRG RGGGRGGRGA PPPPRGRGAP PPRGRAGYSQ RGAPLGPPRG 540
SRGGRGGPAQ QQRGRGSRGA RGNRGGNVGG KRKADGYNQP DSKRRQTNNQ QNWGSQPIAQ 600
QPLQQGGDYS GNYGYNNDNQ EFYQDTYGQQ WK 632 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003676; F:nucleic acid binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro. 
Interpro
 IPR006535; HnRNP_R/Q_splicing_fac.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS