CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017153
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinol dehydrogenase 10 
Protein Synonyms/Alias
  
Gene Name
 RDH10 
Gene Synonyms/Alias
 UNQ9375/PRO34191 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
121TYTCDVGKRENVYLTubiquitination[1]
134LTAERVRKEVGEVSVubiquitination[2]
319YRFLGADKCMYPFIAubiquitination[3, 4, 5, 6]
338ATNNNEAKNGI****ubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. 
Sequence Annotation
 NP_BIND 40 64 NADP (By similarity).
 ACT_SITE 210 210 Proton acceptor (By similarity).
 BINDING 197 197 Substrate (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; Membrane; Microsome; NADP; Oxidoreductase; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR LFALEFARRR 60
ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG EEEILPHCNL QVFTYTCDVG 120
KRENVYLTAE RVRKEVGEVS VLVNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF 180
LPTMLEINHG HIVTVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL 240
VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK 300
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I 341 
Gene Ontology
 GO:0044297; C:cell body; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0052650; F:NADP-retinol dehydrogenase activity; IEA:EC.
 GO:0004745; F:retinol dehydrogenase activity; IDA:UniProtKB.
 GO:0060449; P:bud elongation involved in lung branching; IEA:Compara.
 GO:0043583; P:ear development; IEA:Compara.
 GO:0031076; P:embryonic camera-type eye development; IEA:Compara.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Compara.
 GO:0008406; P:gonad development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0014032; P:neural crest cell development; IEA:Compara.
 GO:0043584; P:nose development; IEA:Compara.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0060431; P:primary lung bud formation; IEA:Compara.
 GO:0042574; P:retinal metabolic process; IDA:UniProtKB.
 GO:0002138; P:retinoic acid biosynthetic process; IEA:Compara.
 GO:0042572; P:retinol metabolic process; IDA:UniProtKB.
 GO:0007601; P:visual perception; IDA:MGI. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.