Tag | Content |
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CPLM ID | CPLM-013609 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-like domain-containing CTD phosphatase 1 |
Protein Synonyms/Alias | Nuclear proteasome inhibitor UBLCP1 |
Gene Name | Ublcp1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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306 | DFLELNHKYWERYLS | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity). |
Sequence Annotation | DOMAIN 3 81 Ubiquitin-like. DOMAIN 133 294 FCP1 homology. REGION 133 294 Phosphatase (By similarity). MOD_RES 117 117 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Hydrolase; Nucleus; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 318 AA |
Protein Sequence | MSLPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV KGKPAENDVK 60 LGALKLKPNT KIMMMGTREE SLEDVLCPPP DNDDVINDFD IEDEVVEVEN REENLLKISR 120 RVKEYKVEVL NPPREGKKLL VLDVDYTLFD HRSCAETGVE LMRPYLHEFL TSAYEDYDIV 180 IWSATNMKWI EAKMKELGVS TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS 240 EFYSKKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLTQY LKEIAKLDDF 300 LELNHKYWER YLSKKQGQ 318 |
Gene Ontology | GO:0005730; C:nucleolus; IEA:Compara. GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. |
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