CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019832
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 A-kinase anchor protein 9 
Protein Synonyms/Alias
 AKAP-9; A-kinase anchor protein 350 kDa; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kDa; AKAP 450; AKAP 120-like protein; Centrosome- and Golgi-localized PKN-associated protein; CG-NAP; Protein hyperion; Protein kinase A-anchoring protein 9; PRKA9; Protein yotiao 
Gene Name
 AKAP9 
Gene Synonyms/Alias
 AKAP350; AKAP450; KIAA0803 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
797SILKDEKKTLEDMLKubiquitination[1]
824FLDSIKSKSKDSVWEubiquitination[2]
1106TQPSENDKLQKELNVubiquitination[2]
1115QKELNVLKSEQNDLRubiquitination[2]
1159DKALCSLKEELIFAQubiquitination[2]
1175EKIKELQKIHQLELQubiquitination[2]
1185QLELQTMKTQETGDEubiquitination[2]
1194QETGDEGKPLHLLIGubiquitination[2]
1205LLIGKLQKAVSEECSubiquitination[2]
1281KVTEEYNKLLVLQTRubiquitination[2]
1291VLQTRLSKIWGQQTDubiquitination[2]
1382AEIHCLQKRLQAVSEubiquitination[2]
1420YPGSCVKKNIDGTIEubiquitination[2]
1446NIVKLLEKQYQEQLEubiquitination[2]
1538KELGEHGKEILLSNSubiquitination[2]
1676LEELEALKQLSLAGRubiquitination[2]
1685LSLAGREKLCCELRNubiquitination[2]
3449GIMQEFQKQELEREEubiquitination[2]
3489RNWVLQQKIEGETKEubiquitination[2]
3495QKIEGETKESNYAKLubiquitination[2]
3529KLQCVASKLQVLPQKubiquitination[2]
3619DLRNMVMKLEEQIRWubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. 
Sequence Annotation
 REGION 2554 2567 PKA-RII subunit binding domain.
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 3846 3846 Phosphoserine.
 MOD_RES 3869 3869 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Golgi apparatus; Long QT syndrome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3911 AA 
Protein Sequence
MEDEERQKKL EAGKAKIEEL SLAFLVRQLA QFRQRKAQSD GQSPSKKQKK KRKTSSSKHD 60
VSAHHDLNID QSQCNEMYIN SSQRVESTVI PESTIMRTLH SGEITSHEQG FSVELESEIS 120
TTADDCSSEV NGCSFVMRTG KPTNLLREEE FGVDDSYSEQ GAQDSPTHLE MMESELAGKQ 180
HEIEELNREL EEMRVTYGTE GLQQLQEFEA AIKQRDGIIT QLTANLQQAR REKDETMREF 240
LELTEQSQKL QIQFQQLQAS ETLRNSTHSS TAADLLQAKQ QILTHQQQLE EQDHLLEDYQ 300
KKKEDFTMQI SFLQEKIKVY EMEQDKKVEN SNKEEIQEKE TIIEELNTKI IEEEKKTLEL 360
KDKLTTADKL LGELQEQIVQ KNQEIKNMKL ELTNSKQKER QSSEEIKQLM GTVEELQKRN 420
HKDSQFETDI VQRMEQETQR KLEQLRAELD EMYGQQIVQM KQELIRQHMA QMEEMKTRHK 480
GEMENALRSY SNITVNEDQI KLMNVAINEL NIKLQDTNSQ KEKLKEELGL ILEEKCALQR 540
QLEDLVEELS FSREQIQRAR QTIAEQESKL NEAHKSLSTV EDLKAEIVSA SESRKELELK 600
HEAEVTNYKI KLEMLEKEKN AVLDRMAESQ EAELERLRTQ LLFSHEEELS KLKEDLEIEH 660
RINIEKLKDN LGIHYKQQID GLQNEMSQKI ETMQFEKDNL ITKQNQLILE ISKLKDLQQS 720
LVNSKSEEMT LQINELQKEI EILRQEEKEK GTLEQEVQEL QLKTELLEKQ MKEKENDLQE 780
KFAQLEAENS ILKDEKKTLE DMLKIHTPVS QEERLIFLDS IKSKSKDSVW EKEIEILIEE 840
NEDLKQQCIQ LNEEIEKQRN TFSFAEKNFE VNYQELQEEY ACLLKVKDDL EDSKNKQELE 900
YKSKLKALNE ELHLQRINPT TVKMKSSVFD EDKTFVAETL EMGEVVEKDT TELMEKLEVT 960
KREKLELSQR LSDLSEQLKQ KHGEISFLNE EVKSLKQEKE QVSLRCRELE IIINHNRAEN 1020
VQSCDTQVSS LLDGVVTMTS RGAEGSVSKV NKSFGEESKI MVEDKVSFEN MTVGEESKQE 1080
QLILDHLPSV TKESSLRATQ PSENDKLQKE LNVLKSEQND LRLQMEAQRI CLSLVYSTHV 1140
DQVREYMENE KDKALCSLKE ELIFAQEEKI KELQKIHQLE LQTMKTQETG DEGKPLHLLI 1200
GKLQKAVSEE CSYFLQTLCS VLGEYYTPAL KCEVNAEDKE NSGDYISENE DPELQDYRYE 1260
VQDFQENMHT LLNKVTEEYN KLLVLQTRLS KIWGQQTDGM KLEFGEENLP KEETEFLSIH 1320
SQMTNLEDID VNHKSKLSSL QDLEKTKLEE QVQELESLIS SLQQQLKETE QNYEAEIHCL 1380
QKRLQAVSES TVPPSLPVDS VVITESDAQR TMYPGSCVKK NIDGTIEFSG EFGVKEETNI 1440
VKLLEKQYQE QLEEEVAKVI VSMSIAFAQQ TELSRISGGK ENTASSKQAH AVCQQEQHYF 1500
NEMKLSQDQI GFQTFETVDV KFKEEFKPLS KELGEHGKEI LLSNSDPHDI PESKDCVLTI 1560
SEEMFSKDKT FIVRQSIHDE ISVSSMDASR QLMLNEEQLE DMRQELVRQY QEHQQATELL 1620
RQAHMRQMER QREDQEQLQE EIKRLNRQLA QRSSIDNENL VSERERVLLE ELEALKQLSL 1680
AGREKLCCEL RNSSTQTQNG NENQGEVEEQ TFKEKELDRK PEDVPPEILS NERYALQKAN 1740
NRLLKILLEV VKTTAAVEET IGRHVLGILD RSSKSQSSAS LIWRSEAEAS VKSCVHEEHT 1800
RVTDESIPSY SGSDMPRNDI NMWSKVTEEG TELSQRLVRS GFAGTEIDPE NEELMLNISS 1860
RLQAAVEKLL EAISETSSQL EHAKVTQTEL MRESFRQKQE ATESLKCQEE LRERLHEESR 1920
AREQLAVELS KAEGVIDGYA DEKTLFERQI QEKTDIIDRL EQELLCASNR LQELEAEQQQ 1980
IQEERELLSR QKEAMKAEAG PVEQQLLQET EKLMKEKLEV QCQAEKVRDD LQKQVKALEI 2040
DVEEQVSRFI ELEQEKNTEL MDLRQQNQAL EKQLEKMRKF LDEQAIDREH ERDVFQQEIQ 2100
KLEQQLKVVP RFQPISEHQT REVEQLANHL KEKTDKCSEL LLSKEQLQRD IQERNEEIEK 2160
LEFRVRELEQ ALLVQDRKHF GAVEAKPELS LEVQLQAERD AIDRKEKEIT NLEEQLEQFR 2220
EELENKNEEV QQLHMQLEIQ KKESTTRLQE LEQENKLFKD DMEKLGLAIK ESDAMSTQDQ 2280
HVLFGKFAQI IQEKEVEIDQ LNEQVTKLQQ QLKITTDNKV IEEKNELIRD LETQIECLMS 2340
DQECVKRNRE EEIEQLNEVI EKLQQELANI GQKTSMNAHS LSEEADSLKH QLDVVIAEKL 2400
ALEQQVETAN EEMTFMKNVL KETNFKMNQL TQELFSLKRE RESVEKIQSI PENSVNVAID 2460
HLSKDKPELE VVLTEDALKS LENQTYFKSF EENGKGSIIN LETRLLQLES TVSAKDLELT 2520
QCYKQIKDMQ EQGQFETEML QKKIVNLQKI VEEKVAAALV SQIQLEAVQE YAKFCQDNQT 2580
ISSEPERTNI QNLNQLREDE LGSDISALTL RISELESQVV EMHTSLILEK EQVEIAEKNV 2640
LEKEKKLLEL QKLLEGNEKK QREKEKKRSP QDVEVLKTTT ELFHSNEESG FFNELEALRA 2700
ESVATKAELA SYKEKAEKLQ EELLVKETNM TSLQKDLSQV RDHLAEAKEK LSILEKEDET 2760
EVQESKKACM FEPLPIKLSK SIASQTDGTL KISSSNQTPQ ILVKNAGIQI NLQSECSSEE 2820
VTEIISQFTE KIEKMQELHA AEILDMESRH ISETETLKRE HYVAVQLLKE ECGTLKAVIQ 2880
CLRSKEGSSI PELAHSDAYQ TREICSSDSG SDWGQGIYLT HSQGFDIASE GRGEESESAT 2940
DSFPKKIKGL LRAVHNEGMQ VLSLTESPYS DGEDHSIQQV SEPWLEERKA YINTISSLKD 3000
LITKMQLQRE AEVYDSSQSH ESFSDWRGEL LLALQQVFLE ERSVLLAAFR TELTALGTTD 3060
AVGLLNCLEQ RIQEQGVEYQ AAMECLQKAD RRSLLSEIQA LHAQMNGRKI TLKREQESEK 3120
PSQELLEYNI QQKQSQMLEM QVELSSMKDR ATELQEQLSS EKMVVAELKS ELAQTKLELE 3180
TTLKAQHKHL KELEAFRLEV KDKTDEVHLL NDTLASEQKK SRELQWALEK EKAKLGRSEE 3240
RDKEELEDLK FSLESQKQRN LQLNLLLEQQ KQLLNESQQK IESQRMLYDA QLSEEQGRNL 3300
ELQVLLESEK VRIREMSSTL DRERELHAQL QSSDGTGQSR PPLPSEDLLK ELQKQLEEKH 3360
SRIVELLNET EKYKLDSLQT RQQMEKDRQV HRKTLQTEQE ANTEGQKKMH ELQSKVEDLQ 3420
RQLEEKRQQV YKLDLEGQRL QGIMQEFQKQ ELEREEKRES RRILYQNLNE PTTWSLTSDR 3480
TRNWVLQQKI EGETKESNYA KLIEMNGGGT GCNHELEMIR QKLQCVASKL QVLPQKASER 3540
LQFETADDED FIWVQENIDE IILQLQKLTG QQGEEPSLVS PSTSCGSLTE RLLRQNAELT 3600
GHISQLTEEK NDLRNMVMKL EEQIRWYRQT GAGRDNSSRF SLNGGANIEA IIASEKEVWN 3660
REKLTLQKSL KRAEAEVYKL KAELRNDSLL QTLSPDSEHV TLKRIYGKYL RAESFRKALI 3720
YQKKYLLLLL GGFQECEDAT LALLARMGGQ PAFTDLEVIT NRPKGFTRFR SAVRVSIAIS 3780
RMKFLVRRWH RVTGSVSINI NRDGFGLNQG AEKTDSFYHS SGGLELYGEP RHTTYRSRSD 3840
LDYIRSPLPF QNRYPGTPAD FNPGSLACSQ LQNYDPDRAL TDYITRLEAL QRRLGTIQSG 3900
ALSLTTSWQH HSARPTAPLF FEILSHSLG 3929 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0000242; C:pericentriolar material; IEA:Compara.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0007268; P:synaptic transmission; TAS:ProtInc.
 GO:0006810; P:transport; TAS:ProtInc. 
Interpro
 IPR019528; PACT_domain. 
Pfam
 PF10495; PACT_coil_coil 
SMART
  
PROSITE
  
PRINTS