CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RRP15-like protein 
Protein Synonyms/Alias
 Ribosomal RNA-processing protein 15 
Gene Name
 RRP15 
Gene Synonyms/Alias
 KIAA0507; CGI-115 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
108NKKTPESKPTILVKNacetylation[1]
156KPDVVQDKETERNLQubiquitination[1]
179QLFNAVQKHQKNVDEubiquitination[2, 3, 4, 5]
207KLISTVSKKDFISVLubiquitination[2, 5]
208LISTVSKKDFISVLRubiquitination[2, 3, 4, 5]
239KAKQTEVKSEEGPGWubiquitination[6]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 11 11 Phosphoserine.
 MOD_RES 58 58 Phosphoserine.
 MOD_RES 67 67 Phosphoserine.
 MOD_RES 104 104 Phosphothreonine.
 MOD_RES 266 266 Phosphoserine.
 MOD_RES 276 276 Phosphoserine.
 MOD_RES 280 280 Phosphoserine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MAAAAPDSRV SEEENLKKTP KKKMKMVTGA VASVLEDEAT DTSDSEGSCG SEKDHFYSDD 60
DAIEADSEGD AEPCDKENEN DGESSVGTNM GWADAMAKVL NKKTPESKPT ILVKNKKLEK 120
EKEKLKQERL EKIKQRDKRL EWEMMCRVKP DVVQDKETER NLQRIATRGV VQLFNAVQKH 180
QKNVDEKVKE AGSSMRKRAK LISTVSKKDF ISVLRGMDGS TNETASSRKK PKAKQTEVKS 240
EEGPGWTILR DDFMMGASMK DWDKESDGPD DSRPESASDS DT 282 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA. 
Interpro
 IPR012459; DUF1665. 
Pfam
 PF07890; Rrp15p 
SMART
  
PROSITE
  
PRINTS