CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038381
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Structural maintenance of chromosomes protein 
Protein Synonyms/Alias
  
Gene Name
 Smc4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
354KKLNKVTKFIEQNKEacetylation[1]
858GKVEAEIKRLHNTIIacetylation[2]
932EKEINDLKTELKNIEacetylation[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1261 AA 
Protein Sequence
MRRKGTKPST ACHQEEGPPP SQDGAHSDEE MEQPAGEAES AAPATMASEA GAPRLMITHI 60
VNQNFKSYAG EKVLGPFHKR FSCIIGPNGS GKSNVIDSML FVFGYRAQKI RSKKLSVLIH 120
NSDEHKDIQS CTVEVHFQKI IDKEGDDYEV LPNSNFYVSR TAYRDSTSVY HISGKKKTFK 180
DVGNLLRSHG IDLDHNRFLI LQGEVEQIAM MKPKGQTEHD EGMLEYLEDI IGCGRLNEPI 240
KVLCRRVEIL NEHRGEKLNR VKMVEKEKDA LEGEKNIAIE FLTLENEMFK KKNHICQYYI 300
YDLQNRIAEI TTQKEKIHED TKEITEKSNV LSNEMKAKNS AVKDVEKKLN KVTKFIEQNK 360
EKFTQLDLED VQVREKLKHA TSKAKKLEKQ LQKDKEKVEE LKSVPAKSKT VINETTTRNN 420
SLEKEREKEE KKLKEVMDSL KQETQGLQKE KEIQEKELMG FNKSVNEARS KMEVAQSELD 480
IYLSRHNTAV SQLSKAKEAL ITASETLKER KAAIKDINTK LPQTQQELKE KEKELQKLTQ 540
EEINLKSLVH DLFQKVEEAK SSLAMNRSRG KVLDAIIQEK KSGRIPGIYG RLGDLGAIDE 600
KYDIAISSCC HALDYIVVDS IDTAQECVNF LKKHNIGIAT FIGLDKMTVW AKKMSKIQTP 660
ENTPRLFDLV KVKNEEIRQA FYFALRDTLV ANNLDQATRV AYQRDRRWRV VTLQGQIIEQ 720
SGTMSGGGSK VMRGRMGSSV IDEISVEEVN KMESQLERHS KQAMQIQEQK VQHEEAVVKL 780
RHSERDMRNT LEKFAASIQG LSEQEEYLCV QIKELEANVL TTAPDRKQQK LLEENVSVFK 840
KEYDAVAEKA GKVEAEIKRL HNTIIDINNR KLKAQQNKLD TINKQLDECA SAITKAQVAI 900
KTADRNLKKA QDSVCRTEKE IKDTEKEIND LKTELKNIED KAEEVINNTK TAETSLPEIQ 960
KEHRNLLQEL KVIQENEHAL QKDALSIKLK LEQIDGHISE HNSKIKYWQK EISKIKLHPV 1020
EDNPVETVAV LSQEELEAIK NPESITNEIA LLEAQCREMK PNLGAIAEYK KKEDLYLQRV 1080
AELDKITSER DNFRQAYEDL RKQRLNEFMA GFYVITNKLK ENYQMLTLGG DAELELVDSL 1140
DPFSEGIMFS VRPPKKSWKK IFNLSGGEKT LSSLALVFAL HHYKPTPLYF MDEIDAALDF 1200
KNVSIVAFYI YEQTKNAQFI IISLRNNMFE ISDRLIGIYK TYNSTKSVAV NPKQIASKGL 1260
C 1261 
Gene Ontology
 GO:0005694; C:chromosome; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0006310; P:DNA recombination; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0051383; P:kinetochore organization; IMP:MGI.
 GO:0010032; P:meiotic chromosome condensation; IMP:MGI.
 GO:0045132; P:meiotic chromosome segregation; IMP:MGI.
 GO:0007062; P:sister chromatid cohesion; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR003395; RecF/RecN/SMC.
 IPR024704; SMC.
 IPR010935; SMC_hinge. 
Pfam
 PF06470; SMC_hinge
 PF02463; SMC_N 
SMART
 SM00968; SMC_hinge 
PROSITE
  
PRINTS