CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein BANP 
Protein Synonyms/Alias
 BEN domain-containing protein 1; Btg3-associated nuclear protein; Scaffold/matrix-associated region-1-binding protein 
Gene Name
 BANP 
Gene Synonyms/Alias
 BEND1; SMAR1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
275SNLSGQGKHGKKQLDacetylation[1]
275SNLSGQGKHGKKQLDubiquitination[2]
278SGQGKHGKKQLDPLTubiquitination[2]
279GQGKHGKKQLDPLTIubiquitination[2]
331RGQSLAVKSFSRRTPubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity). 
Sequence Annotation
 DOMAIN 226 322 BEN.
 REGION 152 342 Interaction with CUX1 and HDAC1 (By
 REGION 320 349 Necessary and sufficient for TP53
 REGION 342 393 DNA-binding (By similarity).  
Keyword
 Alternative splicing; Cell cycle; Chromatin regulator; Coiled coil; Complete proteome; Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 519 AA 
Protein Sequence
MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD PSIKTICLRL 60
DSIEAKLQAL EATCKSLEEK LDLVTNKQHS PIQVPMVAGS PLGATQTCNK VRCVVPQTTV 120
ILNNDRQNAI VAKMEDPLSN RAPDSLENVI SNAVPGRRQN TIVVKVPGQE DSHHEDGESG 180
SEASDSVSSC GQAGSQSIGS NVTLITLNSE EDYPNGTWLG DENNPEMRVR CAIIPSDMLH 240
ISTNCRTAEK MALTLLDYLF HREVQAVSNL SGQGKHGKKQ LDPLTIYGIR CHLFYKFGIT 300
ESDWYRIKQS IDSKCRTAWR RKQRGQSLAV KSFSRRTPNS SSYCPSEPMM STPPPASELP 360
QPQPQPQALH YALANAQQVQ IHQIGEDGQV QVGHLHIAQV PQGEQVQITQ DSEGNLQIHH 420
VGQDGQLLEA TRIPCLLAPS VFKASSGQVL QGAQLIAVAS SDPAAAGVDG SPLQGSDIQV 480
QYVQLAPVSD HTAGAQTAEA LQPTLQPEMQ LEHGAIQIQ 519 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0042177; P:negative regulation of protein catabolic process; IEA:Compara.
 GO:0034504; P:protein localization to nucleus; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR018379; BEN_domain. 
Pfam
 PF10523; BEN 
SMART
 SM01025; BEN 
PROSITE
 PS51457; BEN 
PRINTS