UniProt Accession

 C9IYK2_HUMAN; C9IYK2 

Genbank Protein ID

 AC024221 

Genbank Nucleotide ID

  

Protein Name

 Structural maintenance of chromosomes protein 4 

Protein Synonyms/Alias

  

Gene Name

 SMC4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	HIVNQNFKSYAGEKI	ubiquitination	[1, 2]
99	FKSYAGEKILGPFHK	ubiquitination	[2]
106	KILGPFHKRFSCIIG	ubiquitination	[2]
153	IHNSDEHKDIQSCTV	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 173 AA 

Protein Sequence

Gene Ontology

 GO:0051383; P:kinetochore organization; IEA:Compara.
 GO:0010032; P:meiotic chromosome condensation; IEA:Compara.
 GO:0045132; P:meiotic chromosome segregation; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR003395; RecF/RecN/SMC. 

Pfam

 PF02463; SMC_N 

SMART

  

PROSITE

  

PRINTS