CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042496
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase HUWE1 
Protein Synonyms/Alias
  
Gene Name
 HUWE1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15EALLKVIKFLGDEQDubiquitination[1]
74KECPFVIKPKIQRPNubiquitination[2]
188PQRAALLKSMLNFLKubiquitination[3]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 228 AA 
Protein Sequence
XVSCGMMEAL LKVIKFLGDE QDQITFVTRA VRVVDLITNL DMAAFQSHSG LSIFIYRLEH 60
EVDLCRKECP FVIKPKIQRP NTTQEGEEME TDMDVADVAM ESSPGSSISM EHRLDVELRA 120
SGSSSSTNIS SGPSPGPSPG TGPGPGPGPG PGPGPGPGPG PGPGPGPGPG PGPRPGVQCI 180
PQRAALLKSM LNFLKKAIQD PAFSDGIRHV MDGSLPTSLK HIISNAEY 228 
Gene Ontology
  
Interpro
 IPR010314; E3_Ub_ligase_DUF913. 
Pfam
 PF06025; DUF913 
SMART
  
PROSITE
  
PRINTS