UniProt Accession

 BSND_MOUSE; Q8VIM4; B1AZI5; Q8C740; Q8CHY0 

Genbank Protein ID

 AF391088; AY373833; AK052587; AL954352; BC038287 

Genbank Nucleotide ID

 AAL33907.1; AAQ81629.1; BAC35049.1; CAM15752.1; AAH38287.1 

Protein Name

 Barttin 

Protein Synonyms/Alias

  

Gene Name

 Bsnd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
89	ETGLSEVKSPQPPYV	ubiquitination	[1]
134	PLLAPELKTGASSVR	ubiquitination	[1]
256	REAALPRKQQWSLRM	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. 

Sequence Annotation

  

Keyword

 Cell membrane; Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 307 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0017081; F:chloride channel regulator activity; IEA:Compara.
 GO:0030644; P:cellular chloride ion homeostasis; NAS:UniProtKB.
 GO:0030007; P:cellular potassium ion homeostasis; NAS:UniProtKB.
 GO:0006821; P:chloride transport; IEA:Compara.
 GO:0007605; P:sensory perception of sound; NAS:UniProtKB. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS