CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043544
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein phosphatase 
Protein Synonyms/Alias
  
Gene Name
 PPP4C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31EVKALCAKAREILVEubiquitination[1]
63HGQFYDLKELFRVRYubiquitination[1, 2]
99FYDECLRKYGSVTVWubiquitination[2]
149QIRTIDRKQEVPHDGubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Iron; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 267 AA 
Protein Sequence
MAEISDLDRQ IEQLRRCELI KESEVKALCA KAREILVEES NVQRVDSPVT VCGDIHGQFY 60
DLKELFRVRY PDRITLIRGN HESRQITQVY GFYDECLRKY GSVTVWRYCT EIFDYLSLSA 120
IIDGKIFCVH GGLSPSIQTL DQIRTIDRKQ EVPHDGPMCD LLWSDPEDTT GWGVSPRGAG 180
YLFGSDVVAQ FNAANDIDMI CRAHQLVMEG YKWHFNETVL TVWSAPNYCY RCGNVAAILE 240
LDEHLQKDFI IFEAAPQETR GIPSKKP 267 
Gene Ontology
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:EC. 
Interpro
 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 
Pfam
 PF00149; Metallophos 
SMART
 SM00156; PP2Ac 
PROSITE
 PS00125; SER_THR_PHOSPHATASE 
PRINTS
 PR00114; STPHPHTASE.