CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042374
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein VPRBP 
Protein Synonyms/Alias
  
Gene Name
 VPRBP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
111AIKLEQVKQSLQRTEubiquitination[1]
272NRISSIGKFISGTPRacetylation[2, 3]
316LLSLLSIKMPITDADubiquitination[1]
331QIRALACKALVGLSRubiquitination[4]
362CQIQQLMKEPVLQDKubiquitination[1, 4]
378SDHVKFCKYAAELIEubiquitination[1, 4]
390LIERVSGKPLLIGTDubiquitination[1, 3]
405VSLARLQKADVVAQSubiquitination[1, 5]
419SRISFPEKELLLLIRubiquitination[1]
432IRNHLISKGLGETATubiquitination[1, 4]
443ETATVLTKEADLPMTubiquitination[4]
633NRRASFPKYGGVDGGubiquitination[1, 3]
757DHYVEFSKHSQDRVIubiquitination[4]
767QDRVIGTKGDIAHIYubiquitination[1, 5]
795PDLANNYKRNCATFNubiquitination[1, 3, 4, 5, 6]
898DLMEERMKSPFGSSFubiquitination[1, 3]
914TFNATDYKPIATIDVacetylation[2]
914TFNATDYKPIATIDVubiquitination[3, 4, 5]
922PIATIDVKRNIFDLCubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1078 AA 
Protein Sequence
VCMHPHNVLS DVVNYTLWLM ECSHASGCCH ATMFFSICFS FRAVLELFDR YDGLRRLVNL 60
ISTLEILNLE DQGALLSDDE IFASRQTGKH TCMALRKYFE AHLAIKLEQV KQSLQRTEGG 120
ILVHPQPPYK ACSYTHEQIV EMMEFLIEYG PAQLYWEPAE VFLKLSCVQL LLQLISIACN 180
WKTYYARNDT VRFALDVLAI LTVVPKIQLQ LAESVDVLDE AGSTVSTVGI SIILGVAEGE 240
FFIHDAEIQK SALQIIINCV CGPDNRISSI GKFISGTPRR KLPQNPKSSE HTLAKMWNVV 300
QSNNGIKVLL SLLSIKMPIT DADQIRALAC KALVGLSRSS TVRQIISKLP LFSSCQIQQL 360
MKEPVLQDKR SDHVKFCKYA AELIERVSGK PLLIGTDVSL ARLQKADVVA QSRISFPEKE 420
LLLLIRNHLI SKGLGETATV LTKEADLPMT AASHSSAFTP VTAAASPVSL PRTPRIANGI 480
ATRLGSHAAV GASAPSAPTA HPQPRPPQGP LALPGPSYAG NSPLIGRISF IRERPSPCNG 540
RKIRVLRQKS DHGAYSQSPA IKKQLDRHLP SPPTLDSIIT EYLREQHARC KNPVATCPPF 600
SLFTPHQCPE PKQRRQAPIN FTSRLNRRAS FPKYGGVDGG CFDRHLIFSR FRPISVFREA 660
NEDESGFTCC AFSARERFLM LGTCTGQLKL YNVFSGQEEA SYNCHNSAIT HLEPSRDGSL 720
LLTSATWSQP LSALWGMKSV FDMKHSFTED HYVEFSKHSQ DRVIGTKGDI AHIYDIQTGN 780
KLLTLFNPDL ANNYKRNCAT FNPTDDLVLN DGVLWDVRSA QAIHKFDKFN MNISGVFHPN 840
GLEVIINTEI WDLRTFHLLH TVPALDQCRV VFNHTGTVMY GAMLQADDED DLMEERMKSP 900
FGSSFRTFNA TDYKPIATID VKRNIFDLCT DTKDCYLAVI ENQGSMDALN MDTVCRLYEV 960
GRQRLAEDED EEEDQEEEEQ EEEDDDEDDD DTDDLDELDT DQLLEAELEE DDNNENAGED 1020
GDNDFSPSDE ELANLLEEGE DGEDEDSDAD EEVELILGDT DSSDNSDLED DIILSLNE 1078 
Gene Ontology
  
Interpro
 IPR006594; LisH_dimerisation.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom. 
Pfam
  
SMART
 SM00667; LisH 
PROSITE
 PS50896; LISH 
PRINTS