CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028668
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Connector enhancer of kinase suppressor of ras 2 
Protein Synonyms/Alias
  
Gene Name
 Cnksr2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
38IKNFEREKISGDQLLubiquitination[1]
294SGVILTLKKRPQSMLubiquitination[1]
476LRYMSNEKIAQEEYMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 896 AA 
Protein Sequence
MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ ELEDLGVSRI 60
GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRTSRKL 120
PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV TDYSVTRNNV IQLCLELTTI VQQDCTVYET 180
ENKILHVCKT LSGVCDHIIS LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV 240
ITGTTENSPA DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN ALREDPSGVI LTLKKRPQSM 300
LTSAPALLKN MRWKPLALQP LIPRSPTSSV ATPSSTISTP TKRDSSALQD LYIPPPPAEP 360
YIPRDEKGNL PCEDLRGHMV GKPVHKGSES PNSFLDQEYR KRFNIVEEDT VLYCYEYEKG 420
RSSSQGRRES TPTYGKLRPI SMPVEYNWVG DYEDPNKMKR DSRRENSLLR YMSNEKIAQE 480
EYMFQRNSKK DTGKKSKKKG DKSNSPAHYS LLPSLQMDAL RQDIMGTPVP ETTLYHTFQQ 540
SSLQHKSKKK NKGAISGKSK RRISCKDLGR GDCEGWLWKK KDAKSYFSQK WKKYWFVLKD 600
ASLYWYINEE DEKAEGFISL PEFKIDRASE CRKKYAFKAC HPKIKSFYFA AEHLDDMNRW 660
LNRINMLTAG YAERERIKQE QDYWSESDKE EADTPSTPKQ DSPPPPYDTY PRPPSMSCAS 720
PYVEAKHSRL SSTETSQSQS SHEEFRQEVT GSSAVSPIRK TASQRRSWQD LIETPLTSSG 780
LHYLQTLPLE DSVFSDSAAI SPEHRRQSTL PTQKCHLQDH YGPYPLAESE RMQVLNGNGG 840
KPRSFTLPRD SGFNHCCLNT PVSACDPQDD IQPPEVEEEE EEEEEEAAGE NVGEKS 896 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0009966; P:regulation of signal transduction; IEA:InterPro. 
Interpro
 IPR010599; CNKSR2.
 IPR017874; CRIC_domain.
 IPR019555; CRIC_domain_Chordata.
 IPR001478; PDZ.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1. 
Pfam
 PF10534; CRIC_ras_sig
 PF06663; DUF1170
 PF00595; PDZ
 PF00169; PH
 PF00536; SAM_1 
SMART
 SM00228; PDZ
 SM00233; PH
 SM00454; SAM 
PROSITE
 PS51290; CRIC
 PS50106; PDZ
 PS50003; PH_DOMAIN
 PS50105; SAM_DOMAIN 
PRINTS